1974～2004年间丹麦青年自我报告哮喘患病率和严重度
2010/08/20
为了明确30年间（1974～2004年）丹麦青年哮喘的患病率和严重度，Browatzki等从哥本哈根3次人口调查(1976～1978, 1991～1993 和2001～2004)中抽取22～35岁青年进行研究。共有3285例(46% male)青年进行了问卷调查、体检和肺功能测定。
研究发现，3次调查中，丹麦青年自我报告哮喘的患病率逐年增长，分别为1.5%、4.7%和6.9%(p<0.001)。男性和女性的哮喘患病率均有所增长，女性增长更为突出。1976～1978年度与2001～2004年度相比，哮喘组和非哮喘组FEV1的差异逐渐加大，分别为2.3 %预计值(p = 0.56) 和14.2%预计值 (p<0.001)。在1991～1994年度的调查中，吸烟者从60%减少至38% (p<0.001)，而肥胖者增加。进一步分析发现，体重指数增加，尤其是>30 kg·m–2，与FEV1下降有具有相关性(p=0.005)，哮喘和肥胖对FEV1有叠加作用。
本研究发现，丹麦青年哮喘的患病率和严重度逐年增加，而哮喘严重度的增加部分是由肥胖者增加造成。
（韩伟 青岛大学附属青岛市立医院东院 266071 摘译）
（Eur Respir J 2009; 34:1046-1051）
Prevalence and severity of self-reported asthma in young adults, 1976–2004
A. Browatzki, C. S. Ulrik1 and P. Lange
The aim of the present study was to describe the prevalence and severity of asthma in young Danish adults over three decades.
Males and females aged 20–35 yrs were sampled from the population of Copenhagen for the three surveys (1976–1978, 1991–1993 and 2001–2004). A total of 3,285 (46% male) subjects answered a questionnaire, and had their height, weight, forced expiratory volume in 1 s (FEV1) and forced vital capacity measured.
The prevalence of self-reported asthma was 1.5, 4.7 and 6.9%, respectively, in the three surveys (p<0.001). An increasing prevalence of asthma was observed in both males and females, although it was highest among females. The difference in FEV1 between asthmatic and nonasthmatic subjects gradually increased, being 2.3 (p = 0.56) and 14.2% of the predicted value (p<0.001), respectively, in 1976–1978 and 2001–2004. From the 1991–1994 survey, increasing body mass index, especially >30 kg·m–2, was associated with a lower percentage predicted FEV1 (p0.005), and further analyses suggested an additive effect of asthma and obesity on FEV1. The proportion of smokers declined from 60 to 38% (p<0.001).
The prevalence and severity of asthma have continued to increase over the last three decades among young Danish adults, and the observed increase in severity seems, at least partly, to be related to the increase in prevalence of obesity.
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国民收入与自我报告喘息和哮喘诊断的关系—— 世界健康调查报告分析
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