在戒烟治疗结束后的12个月伐伦克林比尼古丁贴片能更有效的减少体重增加：一项来自日本的观察性研究
2014/06/17
摘要
背景：虽然伐伦克林和尼古丁贴片在控制戒烟后体重增加方面都有疗效，但两者间是否存在差异并不明确。
方法：我们在4家进行戒烟治疗(SCT)的日本医院进行多机构研究，以比较伐伦克林(n = 307)和尼古丁贴片使用者(n = 45)在SCT结束后的第一阶段到12个月的体重变化。
结果：从基线到SCT结束后的12个月，平均体重的变化：伐伦克林使用者+0.94kg (标准差SD: 3.59)，尼古丁贴片使用者+2.78kg (标准差SD: 4.88) （p = 0.003, t检验)。在校正戒烟成功、年龄、性别、并发症和基线身高体重指数、Fagerström尼古丁依赖测试结果、SCT治疗结束后吸烟欲望和SCT过程中的恶心后，多元线性回归分析显示伐伦克林使用者较尼古丁贴片使用者体重增加显著减少(系数: -1.787, 95%可信区间 -2.98 to -0.59)。
结论：我们的结果表明在接受日本SCT的吸烟者中，伐伦克林比尼古丁贴片能更有效的减少体重增加。
（刘国梁 审校）
Nicotine Tob Res. 2014 Apr 4. [Epub ahead of print]
Varenicline Is More Effective in Attenuating Weight Gain Than Nicotine Patch 12 Months After the End of Smoking Cessation Therapy: An Observational Study in Japan.
Taniguchi C1, Tanaka H, Nakamura N, Saka H, Oze I, Ito H, Tachibana K, Tokoro A, Nozaki Y, Nakamichi N, Sakakibara H.
ABSTRACT
INTRODUCTION: Although both varenicline and nicotine patch have a beneficial effect in controlling postcessation weight gain, it is not well known whether there is a difference in the effect.
METHODS: We conducted a multi-institutional study on smoking cessation therapy (SCT) administered at 4 Japanese hospitals to compare the body weight change from the first session to 12 months after the end of SCT (at 60 weeks) between varenicline users (n = 307) and nicotine patch users (n = 45).
RESULTS: The mean weight change from baseline to 12 months after the end of SCT was +0.94kg (SD: 3.59) in varenicline users and +2.78kg (SD: 4.88) in nicotine patch users (p = .003, by t test). In multivariate linear regression analysis, varenicline users gained significantly less weight than nicotine patch users (coefficient: -1.787, 95% CI = -2.98 to -0.59) with adjustment for success of quit smoking, age, sex, presence of comorbidity, body mass index at baseline, Fagerström Test for Nicotine Dependence, craving at the end of SCT, and nausea through the SCT.
CONCLUSION: Our results indicated that varenicline is more effective in attenuating weight gain than nicotine patch in smokers who received Japanese SCT.
Nicotine Tob Res. 2014 Apr 4. [Epub ahead of print]
