哮喘联盟

   摘要
   研究依据：大量随机对照试验的网络meta分析和现实比较研究表明，瓦伦尼克林在帮助戒烟方面比单纯应用尼古丁替代疗法（NRT）更加有效。为这些导致差异的健康因素建模，本需要终身随访，但目前随访只到12个月。长期随访数据有助于验证这些假设。
   目的：本研究旨在比较应用瓦伦尼克林和尼古丁贴片的36月持续戒烟率。
   方法：2006年2月～2009年8月间，587名来自高雄荣民总医院的吸烟者纳入研究。受试者接受内科医生的建议，接受瓦伦尼克林（N=296）或尼古丁贴片（N=291）戒烟治疗。瓦伦尼克林治疗组和尼古丁贴片治疗组均最多接受8周的治疗。在首次随访后的3、6、12、36个月对受试者进行电话随访。主要终点是自报的36月持续戒烟情况。同时检测受试者的吸烟特征、香烟依赖性和社会人口特征。
   结果：在校正其他基线变量后对36月持续戒烟情况进行多元逻辑回归分析，发现瓦伦尼克林组优势明显（OR = 7.94 (95 % CI 1.87-33.74)）。
   结论：在允许行为支持的日常临床实践中，8周瓦伦尼克林治疗与相同治疗时间的尼古丁贴片相比能获得更高的3年戒烟率。
 

（刘国梁 审校）
Psychopharmacology (Berl). 2014 Feb 13. [Epub ahead of print]

 

Varenicline versus transdermal nicotine patch: a 3-year follow-up in a smoking cessation clinic in Taiwan.
 

Hsueh KC, Hsueh SC, Chou MY, Pan LF, Tu MS, McEwen A, West R.
 

Abstract
RATIONALE: A network meta-analysis of randomized trials and real-world comparative studies strongly suggest that varenicline is more effective in aiding smoking cessation than single form nicotine replacement therapy (NRT). Modeling the health benefits attributable to this difference relies on extrapolation to lifetime cessation, but to date, follow-up has only extended to 12 months. Longer term follow-up data are helpful in checking these assumptions.
OBJECTIVES: This study aimed to compare the sustained abstinence rates of smokers using varenicline versus nicotine patch in their quit attempt up to 36 months.
METHOD: Five hundred eighty-seven smokers were recruited at Kaohsiung Veteran General Hospital between Feb 2006 and Aug 2009. Participants received counseling from a physician and received either varenicline (N = 296) or the nicotine patch (N = 291) for smoking cessation. Both varenicline and nicotine patch users could receive their medications for a maximum of 8 weeks. Participants were followed up by telephone at 3, 6, 12, and 36 months from the first visit. The primary outcome measure was self-reported sustained abstinence up to 36 months. Measures were also taken of smoking characteristics, cigarette dependence, and sociodemographic characteristics.
RESULTS: Multiple logistic regression of 36-month sustained abstinence on to medication adjusting for other baseline variables showed a significant advantage for varenicline, OR = 7.94 (95 % CI 1.87-33.74).
CONCLUSION: An 8-week course of varenicline appears to yield higher abstinence rate up to 3 years than a similar length course of nicotine transdermal patch in routine clinical practice where behavioral support is available.
 

Psychopharmacology (Berl). 2014 Feb 13. [Epub ahead of print]