父母的职业是儿童喘息和哮喘的危险因素之一
2010/02/23
该出生－队列研究旨在评估儿童喘息和哮喘是否与父母暴露于会导致哮喘的职业过敏原有关。Avon地区对父母与儿童的纵向研究显示，父母职业与1～102个月儿童的喘息、哮喘、通气功能气道反应性和特应性相关。
本研究调查了出生前11,193例母亲和9,473例父亲的职业，以及出生后4,631例母亲和5315例父亲的职业。
儿童呼吸道疾病转归与父母职业性暴露于二异氰酸酯、胶水/树脂、染料、动物粉尘、焊料、酶素及木尘无关。母亲产后职业性暴露于乳胶和/或杀虫剂/杀真菌药能增加儿童喘息和哮喘的发生风险。高水平乳胶或杀虫剂/杀真菌药暴露与喘息显著相关，OR分别为1.26 （1.07-1.50）和1.22（1.02-2.05），该相关性持续至81个月。乳胶和杀虫剂/杀真菌药联合暴露能增加儿童喘息（OR 1.22 [1.03-1.43]）和哮喘的风险。父母高水平面粉尘暴露与30个月后发生喘息（OR 2.31 [1.05-5.10]）和91个月内出现哮喘（OR 3.23 [1.34-7.79]）的可能性增加相关。
母亲职业暴露于乳胶和/或杀虫剂，及父母暴露于面粉尘能增加儿童哮喘发生的风险。但需进一步深入研究。
（苏楠 审校）
Eur Respir J. 2009 Nov 19. [Epub ahead of print]
Parental occupation is a risk factor for childhood wheeze and asthma.
Tagiyeva N, Devereux G, Semple S, Sherriff A, Henderson J, Elias P, Ayres JG.
University of Aberdeen, Aberdeen, AB252ZP, UK.
This birth-cohort study investigated whether childhood wheeze and asthma is associated with parental exposure to occupational sensitisers that cause asthma.Parental occupation from the Avon Longitudinal Study of Parents and Children was related to wheeze, asthma, ventilatory function, airway responsiveness and atopic sensitisation in children aged 0-102 months.Occupation was recorded for 11,193 mothers and 9,473 fathers ante-natally, and for 4,631 mothers and 5,315 fathers post-natally. Childhood respiratory outcomes were not associated with parental occupational exposure to diisocyanates, glues/resins, dyes, animal dust, solder, enzymes, and wood-dust. Maternal post-natal occupational exposure to latex and/or biocide/fungicides increased the likelihood of childhood wheeze and asthma. High levels of latex or biocide/fungicide exposure were associated with odds ratios of 1.26 [1.07-1.50] and 1.22 [1.02-2.05] respectively for wheezing up to 81 months. Combined maternal latex and biocide/fungicide exposures increased the likelihood of childhood wheeze (OR 1.22 [1.03-1.43]) and asthma. High paternal occupational flour dust exposure was associated with an increased likelihood of wheeze after 30 months (OR 2.31 [1.05-5.10]) and asthma by 91-months (OR 3.23 [1.34-7.79]).Maternal occupational exposure to latex and/or biocides and paternal exposure to flour dust increases the risk of childhood asthma. Further studies in this area are justified
Eur Respir J. 2009 Nov 19. [Epub ahead of print]
本研究调查了出生前11,193例母亲和9,473例父亲的职业，以及出生后4,631例母亲和5315例父亲的职业。
儿童呼吸道疾病转归与父母职业性暴露于二异氰酸酯、胶水/树脂、染料、动物粉尘、焊料、酶素及木尘无关。母亲产后职业性暴露于乳胶和/或杀虫剂/杀真菌药能增加儿童喘息和哮喘的发生风险。高水平乳胶或杀虫剂/杀真菌药暴露与喘息显著相关，OR分别为1.26 （1.07-1.50）和1.22（1.02-2.05），该相关性持续至81个月。乳胶和杀虫剂/杀真菌药联合暴露能增加儿童喘息（OR 1.22 [1.03-1.43]）和哮喘的风险。父母高水平面粉尘暴露与30个月后发生喘息（OR 2.31 [1.05-5.10]）和91个月内出现哮喘（OR 3.23 [1.34-7.79]）的可能性增加相关。
母亲职业暴露于乳胶和/或杀虫剂，及父母暴露于面粉尘能增加儿童哮喘发生的风险。但需进一步深入研究。
（苏楠 审校）
Eur Respir J. 2009 Nov 19. [Epub ahead of print]
Parental occupation is a risk factor for childhood wheeze and asthma.
Tagiyeva N, Devereux G, Semple S, Sherriff A, Henderson J, Elias P, Ayres JG.
University of Aberdeen, Aberdeen, AB252ZP, UK.
This birth-cohort study investigated whether childhood wheeze and asthma is associated with parental exposure to occupational sensitisers that cause asthma.Parental occupation from the Avon Longitudinal Study of Parents and Children was related to wheeze, asthma, ventilatory function, airway responsiveness and atopic sensitisation in children aged 0-102 months.Occupation was recorded for 11,193 mothers and 9,473 fathers ante-natally, and for 4,631 mothers and 5,315 fathers post-natally. Childhood respiratory outcomes were not associated with parental occupational exposure to diisocyanates, glues/resins, dyes, animal dust, solder, enzymes, and wood-dust. Maternal post-natal occupational exposure to latex and/or biocide/fungicides increased the likelihood of childhood wheeze and asthma. High levels of latex or biocide/fungicide exposure were associated with odds ratios of 1.26 [1.07-1.50] and 1.22 [1.02-2.05] respectively for wheezing up to 81 months. Combined maternal latex and biocide/fungicide exposures increased the likelihood of childhood wheeze (OR 1.22 [1.03-1.43]) and asthma. High paternal occupational flour dust exposure was associated with an increased likelihood of wheeze after 30 months (OR 2.31 [1.05-5.10]) and asthma by 91-months (OR 3.23 [1.34-7.79]).Maternal occupational exposure to latex and/or biocides and paternal exposure to flour dust increases the risk of childhood asthma. Further studies in this area are justified
Eur Respir J. 2009 Nov 19. [Epub ahead of print]
