产前激素治疗降低极低出生体重婴儿儿童时期的哮喘风险但无支气管肺发育不良
2010/02/22
支气管肺发育不良（BPD）和极低出生体重（VLBW）与儿童哮喘和肺功能异常的发生显著相关。然而，未见有关试验在VLBW但无BPD的儿童中研究哮喘危险因素。为此，我们在117例VLBW（<1500 g，平均胎龄[GA]：30周）但无BPD的儿童（平均年龄5岁）中研究哮喘发生率和相关危险因素。危险因素包括产期因素（激素使用、机械通气、表面活性剂的使用）和环境因素（父母吸烟、饲养宠物等）。
哮喘的发生率为18.8％。多变量分析显示，家族性特应性是儿童哮喘较强的危险因素。母亲产前激素治疗与哮喘风险下降显著相关。GA和出生体重不是儿童哮喘的预测因子。
上述结果显示，家族性过敏史和产前激素使用分别与极低出生体重（独立于BPD）儿童哮喘分别成正相关和负相关性。关于产前激素使用的作用尚需更多的研究证实。
（林江涛 审校）
J Perinat Med. 2009 Nov 18. [Epub ahead of print]
Antenatal steroid treatment reduces childhood asthma risk in very low birth weight infants without bronchopulmonary dysplasia.
Hung YL, Hsieh WS, Chou HC, Yang YH, Chen CY, Tsao PN.
Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan.
Abstract Bronchopulmonary dysplasia (BPD) and very low birth weight (VLBW) are associated with increased incidences of asthma and pulmonary dysfunction in childhood. However, no studies exist which examine asthma risk factors in children who were VLBW infants and did not have BPD. To address this issue, we assessed the asthma incidence and risk factors for asthma in 117 children (approximate mean age of 5 years) who were VLBW [<1500 g, mean gestational age (GA): 30 weeks] infants without BPD. The risk factors were both perinatal (such as steroid treatment, mechanical ventilation, surfactant treatment) and environmental (parental smoking, pet adoption, etc). The asthma incidence was 18.8%. Following multivariate analysis, it was determined that a family history of atopy was a strong risk factor for childhood asthma. Maternal antenatal steroid treatment was associated with a significantly reduced risk for asthma. GA and birth weight were not predictive of childhood asthma. These findings indicate that a history of familial atopy and antenatal steroid treatment are positively and negatively associated (independent of BPD) with childhood asthma in VLBW infants. The finding regarding antenatal steroid treatment warrants more extensive investigations
J Perinat Med. 2009 Nov 18. [Epub ahead of print]
哮喘的发生率为18.8％。多变量分析显示，家族性特应性是儿童哮喘较强的危险因素。母亲产前激素治疗与哮喘风险下降显著相关。GA和出生体重不是儿童哮喘的预测因子。
上述结果显示，家族性过敏史和产前激素使用分别与极低出生体重（独立于BPD）儿童哮喘分别成正相关和负相关性。关于产前激素使用的作用尚需更多的研究证实。
（林江涛 审校）
J Perinat Med. 2009 Nov 18. [Epub ahead of print]
Antenatal steroid treatment reduces childhood asthma risk in very low birth weight infants without bronchopulmonary dysplasia.
Hung YL, Hsieh WS, Chou HC, Yang YH, Chen CY, Tsao PN.
Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan.
Abstract Bronchopulmonary dysplasia (BPD) and very low birth weight (VLBW) are associated with increased incidences of asthma and pulmonary dysfunction in childhood. However, no studies exist which examine asthma risk factors in children who were VLBW infants and did not have BPD. To address this issue, we assessed the asthma incidence and risk factors for asthma in 117 children (approximate mean age of 5 years) who were VLBW [<1500 g, mean gestational age (GA): 30 weeks] infants without BPD. The risk factors were both perinatal (such as steroid treatment, mechanical ventilation, surfactant treatment) and environmental (parental smoking, pet adoption, etc). The asthma incidence was 18.8%. Following multivariate analysis, it was determined that a family history of atopy was a strong risk factor for childhood asthma. Maternal antenatal steroid treatment was associated with a significantly reduced risk for asthma. GA and birth weight were not predictive of childhood asthma. These findings indicate that a history of familial atopy and antenatal steroid treatment are positively and negatively associated (independent of BPD) with childhood asthma in VLBW infants. The finding regarding antenatal steroid treatment warrants more extensive investigations
J Perinat Med. 2009 Nov 18. [Epub ahead of print]
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父母的职业是儿童喘息和哮喘的危险因素之一
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基于全球哮喘防治倡议的哮喘严重程度及其决定因素：国际性研究
