应用司来吉兰透皮给药系统辅助戒烟
2011/10/11
摘要
前言：本试验在重度吸烟者中研究应用司来吉兰透皮给药系统(STS)和简化重复行为干预(BRBI)戒烟的有效性和安全性。我们认为，采用STS和BRBI戒烟的吸烟者，戒断率显著高于那些采用安慰剂和BRBI的吸烟者。
方法：本试验为一项双盲、安慰剂-对照、平行分组研究。246名受试者参与本项研究，随机分为STS（n = 121）或安慰剂贴剂(n =125)组治疗9周。严重吸烟定义为主诉研究开始之前30天，每天吸烟≥15支，而且吸烟时间超过5年，筛查时呼出气CO水平≥9 ppm。
结果：虽然吸烟者对STS能较好耐受，但总体结果显示，在戒烟方面，联合STS和BRBI治疗的效果并不优于安慰剂联合BRBI治疗(p =0.58)
结论：我们对重度吸烟者的干预结果进行了讨论。虽然2项采用司来吉兰口服戒烟的试验均显示其能改善戒烟，不过我们的结果发现，STS联合BRBI治疗10周、14周和26周，并不能有效的帮助戒烟。
（陈欣 审校）
Nicotine Tob Res. 2011 Aug 16. [Epub ahead of print]
Selegiline Transdermal System (STS) as an Aid for Smoking Cessation.
Kahn R, Gorgon L, Jones K, McSherry F, Glover ED, Anthenelli RM, Jackson T, Williams J, Murtaugh C, Montoya I, Yu E, Elkashef A.
Source
Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, 6001 Executive Boulevard. Room 4123, MSC 9551, Bethesda, MD 20892, USA. rkan@nida.nih.gov.
Abstract
INTRODUCTION: This study examined the efficacy and safety of selegiline transdermal system (STS) and brief repeated behavioral intervention (BRBI) for smoking cessation in heavy smokers. We hypothesized that the quit rate of subjects who received STS and BRBI would be significantly greater than that of those who received placebo patch and BRBI.
METHODS: This was a double-blind, placebo-controlled parallel-group study in which 246 men and women were randomized to receive either STS (n = 121) or placebo patch (n =125) for 9 weeks. Recruitment targeted heavy smokers, defined as individuals with self-reported use of ≥15 cigarettes/day in the 30 days prior to enrollment, who had smoked cigarettes for the past 5 years, and had an expired CO level ≥9 ppm during screening.
RESULTS: Although STS was well tolerated, the overall results indicated that STS with BRBI was not more effective than placebo plus BRBI for smoking cessation (p = .58).
Conclusions: The results are discussed in relation to interventions for heavy smokers. Although 2 trials using oral selegiline both showed trends toward improved abstinence, these results indicate that STS with BRBI was not an effective aid for smoking cessation at the end of treatment (10 weeks), 14, or 26 weeks.
Nicotine Tob Res. 2011 Aug 16. [Epub ahead of print]
