戒烟后痰液基质金属蛋白酶9持续6个月增加
2010/07/05
背景：戒烟是预防吸烟相关气道疾病进展的最佳方法。然而，戒烟对气道炎症/重构的影响及其时相了解甚少。本项前瞻性研究旨在评价戒烟对诱导痰液（IS）中的中性粒细胞、基质金属蛋白酶（MMP-7, -8, -9）、组织金属蛋白酶抑制剂-1（TIMP-1）的影响。
方法：61名吸烟者参与本项研究，17名吸烟者戒烟长达3个月，9名吸烟者戒烟长达6个月。在基线状态和戒烟后3个月、6个月，检测诱导痰液的中性粒细胞比例、MMPs及TIMP-1水平（ELISA检测）。
结果：在吸烟者中，基线状态IS中性粒细胞、MMPs及TIMP-1水平显著高于非吸烟者。戒烟后3个月，研究对象MMP-7, -8及TIMP-1水平降至与非吸烟者相当的水平，但MMP-9仍然高于基线状态值（P=0.009），且持续到戒烟后6个月而无显著变化。
结论：痰液MMP-9即使在戒烟后6个月仍然高于基线水平，这有可能导致肺部损伤，特别是导致COPD。
（刘国梁 审校）
Louhelainen N, et al. BMC Pulm Med. 2010 Mar 14;10(1):13. [Epub ahead of print]Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: a research study.
Louhelainen N, Stark H, Mazur W, Rytila P, Djukanovic R, Kinnula VL.
BACKGROUND: Smoking cessation is the best possible way to prevent the progression of smoking related airway diseases. However, the effect and time scale of smoking cessation on airway inflammation/remodelling are largely unknown. This prospective study evaluated the effects of smoking cessation on induced sputum (IS) neutrophils, matrix metalloproteinases (MMP-7, -8, -9) and tissue inhibitor of metalloproteinase-1 (TIMP-1).
METHODS: A total of 61 subjects participated in the study; 17 stopped smoking for 3 months and 9 for 6 months. The proportion of IS neutrophils and the levels of MMPs and TIMP-1 by ELISA were determined at baseline and at 3 and 6 months after cessation.
RESULTS: In the smokers, baseline IS neutrophils, MMPs and TIMP-1 were significantly higher compared to non-smokers. Levels of MMP-7, -8 and TIMP-1 decreased nearly to those of non-smokers but the levels of MMP-9 increased significantly from the baseline of the same subjects at 3 months after cessation (p=0.009) with no significant decline at 6 months after cessation.
CONCLUSIONS: Sputum MMP-9 remained elevated after 6 months of smoking cessation, which may contribute to ongoing lung damage typical of COPD.
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在鸦片样肽维持治疗的患者中戒烟对违禁药物使用的影响：初步研究
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孕妇孕期戒烟：系统性综述
