哮喘联盟

   摘要
   越来越多的证据表明维生素D调节免疫应答。也有流行病学证据表明维生素D缺乏与哮喘的发展有关。此外，一些流行病学研究表明在妊娠和生命早期低水平维生素D与童年时期呼吸道感染和喘息发展的风险呈负相关。维生素D也可减少哮喘急性发作以及增加对糖皮质激素的反应。这些研究结果发现过敏性呼吸道疾病的发生与低水平维生素D可能存在着联系。然而，维生素D在哮喘发病机制中的确切作用仍不清楚，强调精心设计临床试验来解释维生素D补充在预防和/或管理疾病中的作用的必要性。本综述评价了维生素D缺乏与童年时期喘息和哮喘之间存在的关系。
 

（林江涛 审校）
Front Biosci (Elite Ed). 2014 Jan 1;6:31-9.

 

Is vitamin D deficiency correlated with childhood wheezing and asthma?
 

Comberiati P1, Tsabouri S2, Piacentini GL1, Moser S1, Minniti F1, Peroni DG1.
 

Abstract
There is increasing evidence that vitamin D regulates immune responses. There is also epidemiological evidence of a relationship between vitamin D deficiency and development of asthma. In addition, several epidemiological studies suggest that low levels of vitamin D during pregnancy and early life are inversely associated with the risk of developing respiratory infections and wheezing in childhood. Vitamin D also seems to reduce asthma exacerbation and increase the response to glucocorticoids. These findings have led to considering a possible link between the occurrence of allergic respiratory diseases and low levels of vitamin D. However, the precise role of vitamin D in the pathogenesis of asthma still remains unclear, emphasizing the need for well-designed trials on vitamin D supplementation to decipher its role in preventing and/or managing the disease. This review examines the relationship that exists between vitamin D deficiency and childhood wheezing and asthma.
 

Front Biosci (Elite Ed). 2014 Jan 1;6:31-9.