哮喘联盟

   摘要
   前言：寻找成功的戒烟干预措施和实施方法，对于提高HIV阳性患者的戒烟率和减少吸烟相关疾病至关重要。本试验比较3种戒烟干预措施在HIV临床治疗机构中使用的疗效。
   方法：基线状态下评价后，209名HIV阳性吸烟者随机分为3个平行组。治疗包括个体咨询+尼古丁替代治疗（NRT）、基于计算机的网络吸烟治疗+NRT以及自助治疗+NRT。治疗开始后的12、24、36和52周，对受试者进行随访，检测吸烟状态。
   结果：戒断率为15-29%，但随时间变化，不同组之间的戒断率无显著差异。受雇者、戒烟期望较高者和情绪紊乱评分较低者更有可能获得戒断（p < 0.01）。每次评价之前的24 h，参与者的吸烟量随时间显著下降（p < 0.001）。
   结论：虽然各组之间的戒断率无显著差异，但结果显示在HIV临床治疗机构中整合戒烟干预措施是可行的，也有望改善戒断率。我们报道的总体戒断率与在多个人群中进行的类似治疗研究结果相似，有必要进一步研究。                  
 

 (林江涛 审校)
Nicotine Tob Res. 2013 Feb 19. [Epub ahead of print]

 

A Randomized Clinical Trial of Smoking Cessation Treatments Provided in HIV Clinical Care Settings.
 
Humfleet GL, Hall SM, Delucchi KL, Dilley JW.

Source
Department of Psychiatry, University of California, San Francisco, CA.

Abstract
INTRODUCTION: Identifying successful smoking treatment interventions and methods of delivery is critical given the smoking rates among HIV-positive populations and the medical implications of smoking in this population. This study compared the efficacy of 3 smoking cessation interventions provided in HIV clinical treatment settings.
METHODS: Following a baseline assessment, 209 HIV-positive smokers were randomly assigned to 1 of 3 conditions in a parallel group design. Treatment conditions were individual counseling plus nicotine replacement treatment (NRT), a computer-based Internet smoking treatment plus NRT, and self-help plus NRT. Smoking status was determined at follow-up assessments completed at 12, 24, 36, and 52 weeks following treatment initiation.
RESULTS: Cessation rates ranged from 15% to 29%; however, no statistically significant differences inabstinence were found among the treatment conditions over time. Those employed, those who reported a greater desire to quit, or those with lower mood disturbance scores were more likely to achieve abstinence (p < .01). The number of cigarettes participants reported smoking in the 24hr prior to each assessment significantly declined over time (p < .001).
CONCLUSIONS: Although we found no differences in abstinence rates across groups, the results indicate that integration of smoking cessation interventions is feasible in HIV clinical treatment settings, and cessation results are promising. The overall abstinence rates we report are comparable to those found in similar treatment studies across multiple populations. Further research is warranted.

Nicotine Tob Res. 2013 Feb 19. [Epub ahead of print]