哮喘患者血清精氨酸酶I水平较高：与高反应性C反应蛋白的关系
2011/03/28
摘要
背景：越来越多的研究关注在哮喘小鼠肺脏中诱导精氨酸酶I。然而，在前期研究中，对于哮喘患者血清精氨酸酶活性的变化并未有一致结论。
目的：本试验旨在评价哮喘患者血清精氨酸酶I 的临床相关性。
方法：在非吸烟的哮喘患者(n=23)和健康个体(n=30)中，采用酶联免疫分析，检测血清精氨酸酶I 水平，研究其与一些临床参数的关系。
结果：哮喘患者的精氨酸酶I 水平(67.4±41.0 ng/mL )显著高于健康对照(27.2±12.9 ng/mL)。在健康对照者，不同性别人群间，精氨酸酶I 水平无显著差异，但不同年龄组间存在差异。对于哮喘患者，血清精氨酸酶I 在不同年龄、不同性别和不同糖皮质激素吸入治疗患者间无显著性差异，但不同过敏状态患者间存在着显著性差异。非过敏性哮喘患者血清精氨酸酶I 水平要高于过敏性哮喘患者和健康对照者，但过敏性哮喘患者与健康对照者之间无显著性差异。相关分析显示，在健康对照者中，血清精氨酸酶I与年龄呈显著负相关，与血细胞计数成正相关。而在哮喘患者，该酶水平与谷丙转氨酶(ALT)、高敏感性C反应蛋白(hs-CRP)呈显著正相关，而与免疫球蛋白E(IgE)呈负相关。
结论：非过敏性哮喘患者血清高水平的精氨酸酶I与气道炎症相关。
（刘国梁 审校）
J Asthma. 2011 Feb;48(1):1-7. Epub 2010 Nov 1.
High serum arginase I levels in asthma: its correlation with high-sensitivity C-reactive protein.
Ogino K, Obase Y, Takahashi N, Shimizu H, Takigawa T, Wang DH, Ouchi K, Oka M.
Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Abstract
Background. Much attention has been directed to the induction of arginase I in the lung of asthmatic mice. However, there is no agreement on the changes of serum arginase activity in asthmatic patients among previous studies.
Objectives. The aim of this study was to evaluate the clinical relevance of serum arginase I in asthmatic patients.
Methods. Serum arginase I was examined cross-sectionally in non-smoking asthmatic patients (n = 23) and healthy individuals (n = 30) using enzyme-linked immunosorbent assay (ELISA) and its correlations with several clinical parameters were investigated.
Results. Serum levels of arginase I were significantly increased in asthmatic patients (mean ± SD 67.4 ± 41.0 ng/mL) compared with healthy controls (27.2 ± 12.9 ng/mL). In healthy controls, a difference in arginase I levels was not observed between sex groups but was observed between age groups. In asthmatic patients, serum arginase I levels were not different between groups of age, sex, and inhalation steroid therapy but were different between groups of atopic status. Non-atopic asthmatic patients revealed significantly high serum arginase I levels compared with atopic asthmatic patients and healthy controls although no difference was observed between atopic asthmatic patients and healthy controls. Spearman’s correlation analysis showed that serum arginase I level had a significant negative correlation with age and a positive correlation with red blood cell numbers in healthy controls, whereas in asthmatic patients, it had significant positive correlations with alanine aminotransferase (ALT), high-sensitivity C-reactive protein (hs-CRP) and a negative correlation with immunoglobulin-E (IgE).
Conclusions. High serum arginase I levels in asthmatic patients may be associated with airway inflammation in non-atopic asthma. Spearman
J Asthma. 2011 Feb;48(1):1-7. Epub 2010 Nov 1.
背景：越来越多的研究关注在哮喘小鼠肺脏中诱导精氨酸酶I。然而，在前期研究中，对于哮喘患者血清精氨酸酶活性的变化并未有一致结论。
目的：本试验旨在评价哮喘患者血清精氨酸酶I 的临床相关性。
方法：在非吸烟的哮喘患者(n=23)和健康个体(n=30)中，采用酶联免疫分析，检测血清精氨酸酶I 水平，研究其与一些临床参数的关系。
结果：哮喘患者的精氨酸酶I 水平(67.4±41.0 ng/mL )显著高于健康对照(27.2±12.9 ng/mL)。在健康对照者，不同性别人群间，精氨酸酶I 水平无显著差异，但不同年龄组间存在差异。对于哮喘患者，血清精氨酸酶I 在不同年龄、不同性别和不同糖皮质激素吸入治疗患者间无显著性差异，但不同过敏状态患者间存在着显著性差异。非过敏性哮喘患者血清精氨酸酶I 水平要高于过敏性哮喘患者和健康对照者，但过敏性哮喘患者与健康对照者之间无显著性差异。相关分析显示，在健康对照者中，血清精氨酸酶I与年龄呈显著负相关，与血细胞计数成正相关。而在哮喘患者，该酶水平与谷丙转氨酶(ALT)、高敏感性C反应蛋白(hs-CRP)呈显著正相关，而与免疫球蛋白E(IgE)呈负相关。
结论：非过敏性哮喘患者血清高水平的精氨酸酶I与气道炎症相关。
（刘国梁 审校）
J Asthma. 2011 Feb;48(1):1-7. Epub 2010 Nov 1.
High serum arginase I levels in asthma: its correlation with high-sensitivity C-reactive protein.
Ogino K, Obase Y, Takahashi N, Shimizu H, Takigawa T, Wang DH, Ouchi K, Oka M.
Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Abstract
Background. Much attention has been directed to the induction of arginase I in the lung of asthmatic mice. However, there is no agreement on the changes of serum arginase activity in asthmatic patients among previous studies.
Objectives. The aim of this study was to evaluate the clinical relevance of serum arginase I in asthmatic patients.
Methods. Serum arginase I was examined cross-sectionally in non-smoking asthmatic patients (n = 23) and healthy individuals (n = 30) using enzyme-linked immunosorbent assay (ELISA) and its correlations with several clinical parameters were investigated.
Results. Serum levels of arginase I were significantly increased in asthmatic patients (mean ± SD 67.4 ± 41.0 ng/mL) compared with healthy controls (27.2 ± 12.9 ng/mL). In healthy controls, a difference in arginase I levels was not observed between sex groups but was observed between age groups. In asthmatic patients, serum arginase I levels were not different between groups of age, sex, and inhalation steroid therapy but were different between groups of atopic status. Non-atopic asthmatic patients revealed significantly high serum arginase I levels compared with atopic asthmatic patients and healthy controls although no difference was observed between atopic asthmatic patients and healthy controls. Spearman’s correlation analysis showed that serum arginase I level had a significant negative correlation with age and a positive correlation with red blood cell numbers in healthy controls, whereas in asthmatic patients, it had significant positive correlations with alanine aminotransferase (ALT), high-sensitivity C-reactive protein (hs-CRP) and a negative correlation with immunoglobulin-E (IgE).
Conclusions. High serum arginase I levels in asthmatic patients may be associated with airway inflammation in non-atopic asthma. Spearman
J Asthma. 2011 Feb;48(1):1-7. Epub 2010 Nov 1.
