经医生诊断的变应性鼻炎是否是哮喘发展中的危险因素？
2010/12/07
摘要
背景：虽然变应性鼻炎（AR）与哮喘之间的关系存在有力证据，但是在变应性鼻炎会导致哮喘却并不清楚。这次研究的目的就是预期性地评估在一大主要关心人群中AR是否是哮喘的诊断中的一个危险因素。
方法：我们进行了一项回顾性队列研究，是从1967年以来在人的四个主要实践活动中预期性地记录终身发病率。课题的两组对象选择如下：（i）一组经确诊为AR的患者（ii）一组使用倾向分数的对照试验。我们在评估对确诊哮喘的风险中，将确诊为AR的病人那组和未确诊为AR的对照组进行比较。
结果：这次研究人群有6491个个体组成（n=2081个AR患者）。平均的随访研究是8.4年。在AR患者中，新诊断为哮喘的占7.6%(n=158),于此相比，对照组为1.6%(n=70)（P<0.001）。因为登记时间，年龄，性别，湿疹与社会经济地位这些因素对哮喘的诊断的影响做了调整后，罹患AR是哮喘发生的危险因素具有统计学意义（OR：4.86%，P<0.001,95%CI：3.5-6.73,对照组如前所示）
结论：在本次研究人群中AR的诊断对于哮喘是个独立的危险因素。一经医生诊断的AR能增加将近五倍罹患哮喘的诊断的风险。
(谢萌 首都儿科研究所 100020 摘译)
（Allergy. 2010 Feb 4）
（原文出自《Allergy》第65期，《Is physician-diagnosed allergic rhinitis a risk factor for the development of asthma?》）
Is physician-diagnosed allergic rhinitis a risk factor for the development of asthma?
Allergy. 2010 Feb 4;
Authors: van den Nieuwenhof L, Schermer T, Bosch Y, Bousquet J, Heijdra Y, Bor H, van den Bosch W, van Weel Co cite this article: van den Nieuwenhof L, Schermer T, Bosch Y, Bousquet J, Heijdra Y, Bor H, van den Bosch W, van Weel C. Is physician-diagnosed allergic rhinitis a risk factor for the development of asthma? Allergy 2010; DOI: 10.1111/j.1398-9995.2009.02316.x.
Abstract
Background: There is strong evidence that there is a relationship between allergic rhinitis (AR) and asthma, but it is unclear whether there is a causal relation between AR and asthma. The aim of this study was to assess prospectively whether AR is a risk factor for the diagnosis of asthma in a large primary care population.
Methods: We performed a historic cohort study of life-time morbidity that had been recorded prospectively since 1967 in four general practices. Two groups of subjects were selected: (i) patients with diagnosis of AR, (ii) a control group matched using propensity scores. We assessed the risk of physician-diagnosed asthma in patients with physician-diagnosed AR compared to subjects without a diagnosis of AR (controls).
Results: The study population consisted of 6491 subjects (n = 2081 patients with AR). Average study follow-up was 8.4 years. In patients with AR, the frequency of newly diagnosed asthma was 7.6% (n = 158) compared to 1.6% (n = 70) in controls (P < 0.001). After adjusting the effect of AR on asthma diagnosis for registration time, age, gender, eczema and socioeconomic status, having AR was a statistically significant risk factor for asthma (hazard ratio: 4.86, P < 0.001, 95% confidence interval: 3.50-6.73, controls as reference).
Conclusion: A diagnosis of AR was an independent risk factor for asthma in our primary care study population. Having physician-diagnosed AR increased the risk almost fivefold for a future asthma diagnosis.
PMID: 20132162 [PubMed - as supplied by publisher]
Keywords:allergic;longitudinal;primary care;risk factor
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哮喘患儿检测肺功能与低住院风险有关：丹麦的一项基于人群的随访研究
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成年新患哮喘的危险因素：以群体为基础的国际队列研究
