蒙特利尔儿童中与哮喘控制较差有关的家庭环境因素：基于人群的研究
2010/09/14
摘要
背景：家庭环境因素可能导致哮喘恶化。较少有试验研究儿童哮喘控制与家庭环境因素之间的关系。
目的：在蒙特利尔小于12岁的哮喘儿童中研究家庭环境因素与哮喘控制较差的相关性。
方法：此项基于人群的横断面研究采用来自2006年蒙特利尔呼吸健康调查研究中的数据，参与儿童（n = 7980）年龄为6个月至12岁。采用加拿大哮喘临床参数共识报告的修订版的临床参数对哮喘控制情况进行评价（n = 980）。运用对数-二项式回归模型，估计现患比（95% CIs），探索哮喘控制不足和家庭环境因素之间的关系。家庭环境因素包括过敏原、刺激物、霉菌和潮湿。比较哮喘得到控制患者与哮喘控制不佳的患者。
结果：调查前1年，98名儿童处于哮喘活动期，36％的儿童满足哮喘控制较差标准中5项中的至少1项。与哮喘控制较差有关的人群特征有年龄较小、父母过敏史、母亲教育水平低、母亲出生于国外、租房居住。经校正后，居住在交通密度较高街道的儿童(PR, 1.35; 95% CI, 1.00-1.81)和卧室或居住在地下室水平的儿童(PR, 1.30; 95% CI, 1.01-1.66)其哮喘控制普遍较差。
结论：哮喘控制欠佳与交通、霉菌和潮湿环境相关，而且后者处于长期暴露，因而对公众健康造成影响。
（陈欣 审校）
J Asthma. 2010 Jun;47(5):513-520.
Home environmental factors associated with poor asthma control in Montreal children: a population-based study
Değer L, Plante C, Goudreau S, Smargiassi A, Perron S, Thivierge RL, Jacques L.
Département de santé environnementale et santé au travail, Université de Montréal, Montréal, Canada.
Abstract
BACKGROUND: Home environmental exposures may aggravate asthma. Few population-based studies have investigated the relationship between asthma control in children and home environmental exposures.
Objective: Identify home environmental exposures associated with poor control of asthma among asthmatic children less than 12 years of age in Montreal (Quebec, Canada).
METHODS: This cross-sectional population-based study used data from a respiratory health survey of Montreal children aged 6 months to 12 years conducted in 2006 (n = 7980). Asthma control was assessed (n = 980) using an adaptation of the Canadian asthma consensus report clinical parameters. Using log-binomial regression models, prevalence ratios (PRs) with 95% confidence intervals (95% CIs) were estimated to explore the relationship between inadequate control of asthma and environmental home exposures, including allergens, irritants, mold, and dampness indicators. Subjects with acceptable asthma control were compared with those with inadequate disease control.
RESULTS: Of 980 children with active asthma in the year prior to the survey, 36% met at least one of the five criteria as to poor control of their disease. The population’s characteristics found to be related with a lack of asthma control were younger age, history of parental atopy, low maternal education level, foreign-born mothers, and tenant occupancy. After adjustments, children living along high-traffic density streets (PR, 1.35; 95% CI, 1.00-1.81) and those with their bedroom or residence at the basement level (PR, 1.30; 95% CI, 1.01-1.66) were found to be at increased risk of poor asthma control.
CONCLUSIONS: Suboptimal asthma control appears to be mostly associated with traffic, along with mold and moisture conditions, the latter being a more frequent exposure and therefore having a greater public health impact.
J Asthma. 2010 Jun;47(5):513-20.
背景：家庭环境因素可能导致哮喘恶化。较少有试验研究儿童哮喘控制与家庭环境因素之间的关系。
目的：在蒙特利尔小于12岁的哮喘儿童中研究家庭环境因素与哮喘控制较差的相关性。
方法：此项基于人群的横断面研究采用来自2006年蒙特利尔呼吸健康调查研究中的数据，参与儿童（n = 7980）年龄为6个月至12岁。采用加拿大哮喘临床参数共识报告的修订版的临床参数对哮喘控制情况进行评价（n = 980）。运用对数-二项式回归模型，估计现患比（95% CIs），探索哮喘控制不足和家庭环境因素之间的关系。家庭环境因素包括过敏原、刺激物、霉菌和潮湿。比较哮喘得到控制患者与哮喘控制不佳的患者。
结果：调查前1年，98名儿童处于哮喘活动期，36％的儿童满足哮喘控制较差标准中5项中的至少1项。与哮喘控制较差有关的人群特征有年龄较小、父母过敏史、母亲教育水平低、母亲出生于国外、租房居住。经校正后，居住在交通密度较高街道的儿童(PR, 1.35; 95% CI, 1.00-1.81)和卧室或居住在地下室水平的儿童(PR, 1.30; 95% CI, 1.01-1.66)其哮喘控制普遍较差。
结论：哮喘控制欠佳与交通、霉菌和潮湿环境相关，而且后者处于长期暴露，因而对公众健康造成影响。
（陈欣 审校）
J Asthma. 2010 Jun;47(5):513-520.
Home environmental factors associated with poor asthma control in Montreal children: a population-based study
Değer L, Plante C, Goudreau S, Smargiassi A, Perron S, Thivierge RL, Jacques L.
Département de santé environnementale et santé au travail, Université de Montréal, Montréal, Canada.
Abstract
BACKGROUND: Home environmental exposures may aggravate asthma. Few population-based studies have investigated the relationship between asthma control in children and home environmental exposures.
Objective: Identify home environmental exposures associated with poor control of asthma among asthmatic children less than 12 years of age in Montreal (Quebec, Canada).
METHODS: This cross-sectional population-based study used data from a respiratory health survey of Montreal children aged 6 months to 12 years conducted in 2006 (n = 7980). Asthma control was assessed (n = 980) using an adaptation of the Canadian asthma consensus report clinical parameters. Using log-binomial regression models, prevalence ratios (PRs) with 95% confidence intervals (95% CIs) were estimated to explore the relationship between inadequate control of asthma and environmental home exposures, including allergens, irritants, mold, and dampness indicators. Subjects with acceptable asthma control were compared with those with inadequate disease control.
RESULTS: Of 980 children with active asthma in the year prior to the survey, 36% met at least one of the five criteria as to poor control of their disease. The population’s characteristics found to be related with a lack of asthma control were younger age, history of parental atopy, low maternal education level, foreign-born mothers, and tenant occupancy. After adjustments, children living along high-traffic density streets (PR, 1.35; 95% CI, 1.00-1.81) and those with their bedroom or residence at the basement level (PR, 1.30; 95% CI, 1.01-1.66) were found to be at increased risk of poor asthma control.
CONCLUSIONS: Suboptimal asthma control appears to be mostly associated with traffic, along with mold and moisture conditions, the latter being a more frequent exposure and therefore having a greater public health impact.
J Asthma. 2010 Jun;47(5):513-20.
上一篇：
2002年～2007年间参与商业保险的人群中未得到控制的哮喘：趋势、预测因素和费用
下一篇：
学校空气质量与儿童干咳、鼻炎和鼻塞有关
