哥斯达黎加儿童哮喘严重程度与血清维生素D水平相关
2010/01/07
母体妊娠期间维生素D的摄入量已被证实与儿童早期哮喘症状负相关。然而尚无研究考察儿童维生素D水平与哮喘严重程度的相关性。作者通过横断面研究，对616名年龄6～14岁的哥斯达黎加地区哮喘儿童进行了25-羟基维生素D水平与过敏及哮喘严重程度相关性分析。
结果：175人（28%）哮喘儿童维生素D水平不足（<30ng/ml）；维生素D水平与总IgE、嗜酸性粒细胞数明显负相关；维生素D一个log单位水平的提高可降低先前住院治疗、抗炎药物使用及气道高反应性的风险性（OR=0.05，OR=0.18，OR=0.15）。
结论：维生素D水平不足在赤道地区儿童哮喘患者中相对常见，低水平维生素D与提高的哮喘及过敏严重程度相关。
（农英 卫生部中日友好医院呼吸内科 100029 摘译）
（Am J Respir Crit Care Med. 2009 May 1;179(9):765-771）
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica.
Brehm JM, Celedón JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, Laskey D, Sylvia JS, Hollis BW, Weiss ST, Litonjua AA.
RATIONALE: Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood.
OBJECTIVES: To determine the relationship between measured vitamin D levels and both markers of asthma severity and allergy in childhood.
Methods: We examined the relation between 25-hydroxyvitamin D levels (the major circulating form of vitamin D) and markers of allergy and asthma severity in a cross-sectional study of 616 Costa Rican children between the ages of 6 and 14 years. Linear, logistic, and negative binomial regressions were used for the univariate and multivariate analyses.
MEASUREMENTS AND MAIN RESULTS: Of the 616 children with asthma, 175 (28%) had insufficient levels of vitamin D (<30 ng/ml). In multivariate linear regression models, vitamin D levels were significantly and inversely associated with total IgE and eosinophil count. In multivariate logistic regression models, a log(10) unit increase in vitamin D levels was associated with reduced odds of any hospitalization in the previous year (odds ratio [OR], 0.05; 95% confidence interval [CI], 0.004-0.71; P = 0.03), any use of antiinflammatory medications in the previous year (OR, 0.18; 95% CI, 0.05-0.67; P = 0.01), and increased airway responsiveness (a < or =8.58-mumol provocative dose of methacholine producing a 20% fall in baseline FEV(1) [OR, 0.15; 95% CI, 0.024-0.97; P = 0.05]).
CONCLUSIONS: Our results suggest that vitamin D insufficiency is relatively frequent in an equatorial population of children with asthma. In these children, lower vitamin D levels are associated with increased markers of allergy and asthma severity.
Am J Respir Crit Care Med. 2009 May 1;179(9):765-771
结果：175人（28%）哮喘儿童维生素D水平不足（<30ng/ml）；维生素D水平与总IgE、嗜酸性粒细胞数明显负相关；维生素D一个log单位水平的提高可降低先前住院治疗、抗炎药物使用及气道高反应性的风险性（OR=0.05，OR=0.18，OR=0.15）。
结论：维生素D水平不足在赤道地区儿童哮喘患者中相对常见，低水平维生素D与提高的哮喘及过敏严重程度相关。
（农英 卫生部中日友好医院呼吸内科 100029 摘译）
（Am J Respir Crit Care Med. 2009 May 1;179(9):765-771）
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica.
Brehm JM, Celedón JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, Laskey D, Sylvia JS, Hollis BW, Weiss ST, Litonjua AA.
RATIONALE: Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood.
OBJECTIVES: To determine the relationship between measured vitamin D levels and both markers of asthma severity and allergy in childhood.
Methods: We examined the relation between 25-hydroxyvitamin D levels (the major circulating form of vitamin D) and markers of allergy and asthma severity in a cross-sectional study of 616 Costa Rican children between the ages of 6 and 14 years. Linear, logistic, and negative binomial regressions were used for the univariate and multivariate analyses.
MEASUREMENTS AND MAIN RESULTS: Of the 616 children with asthma, 175 (28%) had insufficient levels of vitamin D (<30 ng/ml). In multivariate linear regression models, vitamin D levels were significantly and inversely associated with total IgE and eosinophil count. In multivariate logistic regression models, a log(10) unit increase in vitamin D levels was associated with reduced odds of any hospitalization in the previous year (odds ratio [OR], 0.05; 95% confidence interval [CI], 0.004-0.71; P = 0.03), any use of antiinflammatory medications in the previous year (OR, 0.18; 95% CI, 0.05-0.67; P = 0.01), and increased airway responsiveness (a < or =8.58-mumol provocative dose of methacholine producing a 20% fall in baseline FEV(1) [OR, 0.15; 95% CI, 0.024-0.97; P = 0.05]).
CONCLUSIONS: Our results suggest that vitamin D insufficiency is relatively frequent in an equatorial population of children with asthma. In these children, lower vitamin D levels are associated with increased markers of allergy and asthma severity.
Am J Respir Crit Care Med. 2009 May 1;179(9):765-771
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孕妇哮喘的控制状况和严重度对后代哮喘发病率的影响：两阶段对照研究
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