目前治疗过敏性鼻炎和支气管哮喘的免疫学方法
2009/05/22
全球有大量人口受到过敏性疾病和哮喘的困扰。对过敏性疾病和哮喘进行药物治疗能在一定程度控制症状，但停药后症状会复发。相反，免疫治疗能以抗原特异性方式调节并纠正潜在的病理性免疫反应。免疫治疗能增加体内IgG（封闭抗体），与体内存在的IgE竞争结合抗原，抑制炎症介质的释放。最近研究显示，免疫治疗通过调节CD4+T细胞的免疫偏离和/或T细胞无反应产生作用。
目前治疗过敏性疾病和哮喘的免疫学方法主要包括采用天然过敏原免疫、对过敏原进行修饰、过敏原多肽/cDNA、抗IgE、佐剂加过敏原，这其中包含有免疫刺激性的DNA序列、细胞因子和细菌产物等。这些方法能够调节免疫反应，对疾病的治疗具有长期作用。
目前治疗过敏性疾病和哮喘的免疫学方法主要包括采用天然过敏原免疫、对过敏原进行修饰、过敏原多肽/cDNA、抗IgE、佐剂加过敏原，这其中包含有免疫刺激性的DNA序列、细胞因子和细菌产物等。这些方法能够调节免疫反应，对疾病的治疗具有长期作用。
（林江涛 审校）
Srivastava D, et al. Inflamm Res. 2009 Mar 31. [Epub ahead of print]
Current immunological approaches for management of allergic rhinitis and bronchial asthma.
A large population world over is affected with allergic diseases and asthma. Pharmacotherapy for allergic diseases and asthma is effective in controlling symptoms but on discontinuation of medication, symptoms reoccur. In contrast, immunotherapy modifies and corrects the underlying pathological immune responses in an antigen-specific manner. Immunotherapy shows an increase in IgG (blocking antibody) that competes with IgE for allergen, inhibiting the release of inflammatory mediators. Recent studies suggest that immunotherapy acts by modifying CD4+ T-cell responses either by immune deviation, T-cell anergy and/or both. Current immunological approaches for management of allergies and asthma involve immunization with native allergen, modified allergen, peptides/cDNA of allergen, anti-IgE, adjuvants coupled allergen, including immunostimulatory DNA sequences, cytokines, and bacterial products. These approaches modulate the immune response and are intended to give long-term benefit.
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临床联合药物治疗未完全控制的轻度哮喘患者的哮喘发作频率：探索性析因分析
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传统中药治疗哮喘和过敏症的有效性及其机制
