变态反应和哮喘的治疗策略
2008/08/13
英国Southampton 大学医学院Stephen Holgate教授的综述：变态反应和哮喘的治疗策略。该文借助丰富的插图，详细介绍了变态反应尤其是变应性哮喘发病的细胞和分子机制，评价糖皮质激素、beta受体激动剂、茶碱及抗组胺药物对过敏性鼻炎、哮喘的治疗作用和地位，重点总结了变应原特异性免疫治疗对Th1/Th2细胞失衡的调节作用。
（蔡闯 广州医学院第一附属医院 广州呼吸疾病研究所 510120 摘译）
（Nature reviews/immunology, 2008;8:218-230）
Treatment strategies for allergy and asthma
Holgate ST, Polosa R
Abstract 摘要
Allergic diseases have reached epidemic proportions worldwide. An understanding of the cellular and soluble mediators that are involved in allergic inflammatory responses not only helps in understanding the mechanisms of current treatments, but is also important for the identification of new targets that are amenable to both small-molecule and biological interventions. There is now considerable optimism with regards to tackling the allergy epidemic in light of improvements in systemic and mucosal allergen-specific immunotherapy, the identification of key cytokines and their receptors that drive T-helper-2-cell polarization, a clearer understanding of the pathways of leukocyte recruitment and the signalling pathways that are involved in cell activation and mediator secretion, and new approaches to vaccine development.
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回顾NAEPP关于哮喘的诊断和治疗指南2007年的第三次专家组报告（EPR-3）
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目前减少尘螨暴露的物理和/或化学方法，并不能有效改善过敏性哮喘患者呼吸功能，减少哮喘发作及用药
