日本男性工人戒烟后的体重变化、心血管危险因素及冠心病预计风险：HIPOP-OHP研究
2010/04/13
目的：研究发现吸烟者戒烟后体重增加，但戒烟后心血管危险因素及冠心病预计风险的变化尚未完全清楚。
方法：研究对象为来自11个工作点的1995名持续参与HIPOPOHP（促进职业健康的高危因素和人群策略）研究的日本男性工人。参与者有吸烟习惯，检测其基础状态和随后4年内心血管危险因素。根据前期队列研究，采用公式计算预计冠心病患病风险。
结果：随访末期，成功戒烟者（戒烟时间至少6个月）体重增加至少2 kg。与持续吸烟者相比，戒烟者下述因素显著恶化：舒张压和收缩压、总胆固醇、甘油三酯和空腹血糖。相反，HDL-胆固醇水平显著增加。若戒烟前冠心病的总体瞬时发病率定为1.00，成功戒烟者尽管体重增加，但其因戒烟引起预计风险为0.76（95%CI: 0.68-0.85）。
结论：戒烟能导致体重增加，冠心病的预计风险在戒烟后显著下降。
（陈欣 审校）
J Atheroscler Thromb. 2010 Jan 16. [Epub ahead of print]
Changes in Weight, Cardiovascular Risk Factors and Estimated Risk of Coronary Heart Disease Following Smoking Cessation in Japanese Male Workers: HIPOP-OHP Study.
Tamura U, Tanaka T, Okamura T, Kadowaki T, Yamato H, Tanaka H, Nakamura M, Okayama A, Ueshima H, Yamagata Z; HIPOP-OHP research group.
Department of Health Sciences, School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Aim: It is well established that people gain weight after smoking cessation; however, changes in cardiovascular risk factors and the estimated risk of coronary heart disease following smoking cessation have yet to be fully clarified.
Methods: The participants were 1,995 Japanese male workers at 11 workplaces who participated continuously in the High-risk and Population Strategy for Occupational Health Promotion (HIPOPOHP) study. Participants with a smoking habit had cardiovascular risk factors measured at baseline and over a 4-yr period. Their estimated incidence risk of coronary heart disease was calculated by a formula based on a previous cohort study.
Results: Successful abstainers who had stopped smoking for at least 6 months at the end of the follow-up period had weight gains of approximately 2 kg. These subjects had significant worsening of the following factors compared to continuing smokers: systolic and diastolic blood pressure, total cholesterol, triglyceride and fasting blood sugar levels. In contrast, HDL-cholesterol levels improved significantly. When the overall instantaneous incidence risk of coronary heart disease prior to smoking cessation was assumed to be 1.00, the estimated risk was 0.76 (95%CI: 0.68-0.85) in successful abstainers due mainly to smoking cessation, despite weight gain.
Conclusion: Although smoking cessation leads to weight gain, the estimated risk of coronary heart disease was decreased markedly by smoking cessation.
J Atheroscler Thromb. 2010 Jan 16. [Epub ahead of print]
方法：研究对象为来自11个工作点的1995名持续参与HIPOPOHP（促进职业健康的高危因素和人群策略）研究的日本男性工人。参与者有吸烟习惯，检测其基础状态和随后4年内心血管危险因素。根据前期队列研究，采用公式计算预计冠心病患病风险。
结果：随访末期，成功戒烟者（戒烟时间至少6个月）体重增加至少2 kg。与持续吸烟者相比，戒烟者下述因素显著恶化：舒张压和收缩压、总胆固醇、甘油三酯和空腹血糖。相反，HDL-胆固醇水平显著增加。若戒烟前冠心病的总体瞬时发病率定为1.00，成功戒烟者尽管体重增加，但其因戒烟引起预计风险为0.76（95%CI: 0.68-0.85）。
结论：戒烟能导致体重增加，冠心病的预计风险在戒烟后显著下降。
（陈欣 审校）
J Atheroscler Thromb. 2010 Jan 16. [Epub ahead of print]
Changes in Weight, Cardiovascular Risk Factors and Estimated Risk of Coronary Heart Disease Following Smoking Cessation in Japanese Male Workers: HIPOP-OHP Study.
Tamura U, Tanaka T, Okamura T, Kadowaki T, Yamato H, Tanaka H, Nakamura M, Okayama A, Ueshima H, Yamagata Z; HIPOP-OHP research group.
Department of Health Sciences, School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
Aim: It is well established that people gain weight after smoking cessation; however, changes in cardiovascular risk factors and the estimated risk of coronary heart disease following smoking cessation have yet to be fully clarified.
Methods: The participants were 1,995 Japanese male workers at 11 workplaces who participated continuously in the High-risk and Population Strategy for Occupational Health Promotion (HIPOPOHP) study. Participants with a smoking habit had cardiovascular risk factors measured at baseline and over a 4-yr period. Their estimated incidence risk of coronary heart disease was calculated by a formula based on a previous cohort study.
Results: Successful abstainers who had stopped smoking for at least 6 months at the end of the follow-up period had weight gains of approximately 2 kg. These subjects had significant worsening of the following factors compared to continuing smokers: systolic and diastolic blood pressure, total cholesterol, triglyceride and fasting blood sugar levels. In contrast, HDL-cholesterol levels improved significantly. When the overall instantaneous incidence risk of coronary heart disease prior to smoking cessation was assumed to be 1.00, the estimated risk was 0.76 (95%CI: 0.68-0.85) in successful abstainers due mainly to smoking cessation, despite weight gain.
Conclusion: Although smoking cessation leads to weight gain, the estimated risk of coronary heart disease was decreased markedly by smoking cessation.
J Atheroscler Thromb. 2010 Jan 16. [Epub ahead of print]
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孕妇孕期戒烟：系统性综述
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吸烟者戒烟后血浆脑源性神经营养因子水平的变化
