葡萄牙成人哮喘患病率——全国性人口调查EPI-ASTHMA研究
2025/04/30
摘要
背景：2010年，葡萄牙成人哮喘患病率为6.8%。目前需要采用更精确方法的当代研究。本研究旨在评估葡萄牙哮喘患病率并识别相关因素。
方法：2021年5月至2024年3月开展了一项全国性人口研究。采用多阶段随机抽样法从初级医疗中筛选成人受试者。第一阶段通过电话筛查访谈收集社会人口学和临床数据。成人哮喘评分（A2评分）≥1的患者进入第二阶段，同时随机抽取5%的A2评分=0者参与。第二阶段包括诊断性访视（体格检查及诊断测试）。计算加权哮喘患病率估计值，并采用多变量逻辑回归模型分析。
结果：共7,556名参与者完成第一阶段，1,857名完成第二阶段。哮喘患病率为7.1%（95%CI=6.3-8.0%），性别、年龄和地区间略有差异。教育水平、哮喘家族史、吸入处方药使用、鼻/眼症状、食物过敏史及既往皮肤过敏试验与哮喘风险升高相关（R²=33%）。A2评分可独立预测哮喘诊断（R²=43%），结合家族史和皮肤过敏试验后预测效能更高（R²=45%）。
结论：葡萄牙成人哮喘患病率为7.1%。哮喘家族史、鼻/眼症状及合并食物过敏与哮喘风险增加显著相关。
Prevalence of asthma in Portuguese adults - the EPI-ASTHMA study, a nationwide population-based survey
Brito D, Jácome C, Bulhões C, Barbosa MJ, Pina N, Alves da Silva A, João C, Gomes D, Lopes F, Quelhas-Santos J, Amorim L, Rodrigues M, Pardal M, Teixeira PM, Jacinto T, Cruz AM, Pereira AM, Marques A, Sousa-Pinto B, Vicente C, Ferreira E, Alves L, Fernandes MI, Vieira R, Amaral R, Sousa R, Costa R, Castanho T, Bernardo F, Correia-de-Sousa J, Fonseca JA; AEPI-ASTHMA Group. Prevalence of asthma in Portuguese adults - the EPI-ASTHMA study, a nationwide population-based surveyAbstract
BACKGROUND:In 2010, 6.8% of the Portuguese adults had asthma. Contemporary studies employing more accurate methods are needed. We aimed to assess asthma prevalence in Portugal and to identify associated-factors.
METHODS:A population-based nationwide study was conducted from May 2021 to March 2024. A multistage random sampling approach was applied to select adults from primary care. Stage 1 involved a telephone screening interview to collect socio-demographic and clinical data. Patients with an Adult Asthma Score (A2 Score) ≥1 were eligible for Stage 2, and 5% of those with an A2 Score = 0 were also invited to participate in Stage 2, which consisted of a diagnostic visit with a physical examination and diagnostic tests. We computed weighted asthma prevalence estimates and multivariable logistic regression models were used.
RESULTS:A total of 7,556 participants completed Stage 1 and 1,857 Stage 2. The prevalence of asthma was 7.1% (95%CI = 6.3-8.0%), with slight differences by sex, age, and region. Education, family history of asthma, inhaler prescription, nasal/ocular symptoms, food allergies, and previous allergy skin tests were associated with an increased risk of asthma (R2 = 33%). Asthma diagnosis could also be predicted by the A2 score, either on its own (R2 = 43%) or in combination with family history and previous allergy skin tests (R2 = 45%).
CONCLUSION:Asthma affects 7.1% of Portuguese adults. Family history of asthma, nasal/ocular symptoms, and comorbid food allergy are associated with increased risk of asthma.
背景：2010年，葡萄牙成人哮喘患病率为6.8%。目前需要采用更精确方法的当代研究。本研究旨在评估葡萄牙哮喘患病率并识别相关因素。
方法：2021年5月至2024年3月开展了一项全国性人口研究。采用多阶段随机抽样法从初级医疗中筛选成人受试者。第一阶段通过电话筛查访谈收集社会人口学和临床数据。成人哮喘评分（A2评分）≥1的患者进入第二阶段，同时随机抽取5%的A2评分=0者参与。第二阶段包括诊断性访视（体格检查及诊断测试）。计算加权哮喘患病率估计值，并采用多变量逻辑回归模型分析。
结果：共7,556名参与者完成第一阶段，1,857名完成第二阶段。哮喘患病率为7.1%（95%CI=6.3-8.0%），性别、年龄和地区间略有差异。教育水平、哮喘家族史、吸入处方药使用、鼻/眼症状、食物过敏史及既往皮肤过敏试验与哮喘风险升高相关（R²=33%）。A2评分可独立预测哮喘诊断（R²=43%），结合家族史和皮肤过敏试验后预测效能更高（R²=45%）。
结论：葡萄牙成人哮喘患病率为7.1%。哮喘家族史、鼻/眼症状及合并食物过敏与哮喘风险增加显著相关。
（中日友好医院呼吸与危重症医学科 沈焜路 摘译 林江涛 审校）
（Pulmonology. 2025 Dec 31; DOI: 10.1080/25310429.2025.2466920）
Prevalence of asthma in Portuguese adults - the EPI-ASTHMA study, a nationwide population-based survey
Brito D, Jácome C, Bulhões C, Barbosa MJ, Pina N, Alves da Silva A, João C, Gomes D, Lopes F, Quelhas-Santos J, Amorim L, Rodrigues M, Pardal M, Teixeira PM, Jacinto T, Cruz AM, Pereira AM, Marques A, Sousa-Pinto B, Vicente C, Ferreira E, Alves L, Fernandes MI, Vieira R, Amaral R, Sousa R, Costa R, Castanho T, Bernardo F, Correia-de-Sousa J, Fonseca JA; AEPI-ASTHMA Group. Prevalence of asthma in Portuguese adults - the EPI-ASTHMA study, a nationwide population-based surveyAbstract
BACKGROUND:In 2010, 6.8% of the Portuguese adults had asthma. Contemporary studies employing more accurate methods are needed. We aimed to assess asthma prevalence in Portugal and to identify associated-factors.
METHODS:A population-based nationwide study was conducted from May 2021 to March 2024. A multistage random sampling approach was applied to select adults from primary care. Stage 1 involved a telephone screening interview to collect socio-demographic and clinical data. Patients with an Adult Asthma Score (A2 Score) ≥1 were eligible for Stage 2, and 5% of those with an A2 Score = 0 were also invited to participate in Stage 2, which consisted of a diagnostic visit with a physical examination and diagnostic tests. We computed weighted asthma prevalence estimates and multivariable logistic regression models were used.
RESULTS:A total of 7,556 participants completed Stage 1 and 1,857 Stage 2. The prevalence of asthma was 7.1% (95%CI = 6.3-8.0%), with slight differences by sex, age, and region. Education, family history of asthma, inhaler prescription, nasal/ocular symptoms, food allergies, and previous allergy skin tests were associated with an increased risk of asthma (R2 = 33%). Asthma diagnosis could also be predicted by the A2 score, either on its own (R2 = 43%) or in combination with family history and previous allergy skin tests (R2 = 45%).
CONCLUSION:Asthma affects 7.1% of Portuguese adults. Family history of asthma, nasal/ocular symptoms, and comorbid food allergy are associated with increased risk of asthma.
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德国哮喘网络（German Asthma Net）：抗IL-5/IL-5(R)治疗应答者的特征分析
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了解哮喘和COPD的儿童期起源：从出生队列和贯穿一生的研究中获得的见解
