肺中的自然杀伤细胞：在哮喘和病毒诱导的发作中的潜在作用？
2023/07/21
摘要
哮喘是一种慢性炎症性气道疾病，其病理生理和免疫机制尚不完全清楚。哮喘发作主要是由呼吸道病毒感染引起的，其特征是症状恶化。尽管有目前的治疗方法，哮喘发作仍然可能危及生命。自然杀伤（NK）细胞是以其抗病毒活性而闻名的先天性淋巴细胞，并且以循环细胞和常驻细胞的形式存在于肺中。然而，它们在哮喘及其发作中的作用仍不清楚。在这篇综述中，我们将讨论NK细胞的激活和功能，这与哮喘和病毒诱导的哮喘发作特别相关。然后，将描述健康个体中NK细胞在肺部稳态中的作用，以及它们在肺部病毒感染期间的功能，重点是与哮喘发作相关的功能。最后，我们将讨论NK细胞在哮喘和病毒诱导的急性加重中的作用，并检查哮喘治疗对NK细胞的影响。
Natural killer cells in the lung: potential role in asthma and virus-induced exacerbation?
Florian Lepretre, Delphine Gras, Pascal Chanez, Catherine Duez
Abstract
Asthma is a chronic inflammatory airway disorder whose pathophysiological and immunological mechanisms are not completely understood. Asthma exacerbations are mostly driven by respiratory viral infections and characterised by worsening of symptoms. Despite current therapies, asthma exacerbations can still be life-threatening. Natural killer (NK) cells are innate lymphoid cells well known for their antiviral activity and are present in the lung as circulating and resident cells. However, their functions in asthma and its exacerbations are still unclear. In this review, we will address NK cell activation and functions, which are particularly relevant for asthma and virus-induced asthma exacerbations. Then, the role of NK cells in the lungs at homeostasis in healthy individuals will be described, as well as their functions during pulmonary viral infections, with an emphasis on those associated with asthma exacerbations. Finally, we will discuss the involvement of NK cells in asthma and virus-induced exacerbations and examine the effect of asthma treatments on NK cells.
哮喘是一种慢性炎症性气道疾病，其病理生理和免疫机制尚不完全清楚。哮喘发作主要是由呼吸道病毒感染引起的，其特征是症状恶化。尽管有目前的治疗方法，哮喘发作仍然可能危及生命。自然杀伤（NK）细胞是以其抗病毒活性而闻名的先天性淋巴细胞，并且以循环细胞和常驻细胞的形式存在于肺中。然而，它们在哮喘及其发作中的作用仍不清楚。在这篇综述中，我们将讨论NK细胞的激活和功能，这与哮喘和病毒诱导的哮喘发作特别相关。然后，将描述健康个体中NK细胞在肺部稳态中的作用，以及它们在肺部病毒感染期间的功能，重点是与哮喘发作相关的功能。最后，我们将讨论NK细胞在哮喘和病毒诱导的急性加重中的作用，并检查哮喘治疗对NK细胞的影响。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Eur Respir Rev. 2023 Jul 12;32(169):230036. doi: 10.1183/16000617.0036-2023. Print 2023 Sep 30.)
(Eur Respir Rev. 2023 Jul 12;32(169):230036. doi: 10.1183/16000617.0036-2023. Print 2023 Sep 30.)
Natural killer cells in the lung: potential role in asthma and virus-induced exacerbation?
Florian Lepretre, Delphine Gras, Pascal Chanez, Catherine Duez
Abstract
Asthma is a chronic inflammatory airway disorder whose pathophysiological and immunological mechanisms are not completely understood. Asthma exacerbations are mostly driven by respiratory viral infections and characterised by worsening of symptoms. Despite current therapies, asthma exacerbations can still be life-threatening. Natural killer (NK) cells are innate lymphoid cells well known for their antiviral activity and are present in the lung as circulating and resident cells. However, their functions in asthma and its exacerbations are still unclear. In this review, we will address NK cell activation and functions, which are particularly relevant for asthma and virus-induced asthma exacerbations. Then, the role of NK cells in the lungs at homeostasis in healthy individuals will be described, as well as their functions during pulmonary viral infections, with an emphasis on those associated with asthma exacerbations. Finally, we will discuss the involvement of NK cells in asthma and virus-induced exacerbations and examine the effect of asthma treatments on NK cells.
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低2型生物标志物重度哮喘和哮喘控制中的血液转录组学特征
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LPS结合蛋白和激活信号在儿童哮喘发作期上调
