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补充石榴提取物是否能改善过敏性哮喘患者的临床症状?一项双盲、随机、安慰剂对照试验

2023/02/20

   摘要
   背景:哮喘本质上是一种慢性炎症性疾病,在哮喘患者的一生中表现为不同严重程度的终身疾病。石榴的抗氧化活性是绿茶等富含多酚食物的三倍,其可能对哮喘有积极影响。
   研究目的:本研究旨在研究补充石榴提取物对过敏性哮喘患者临床症状、嗜酸性粒细胞、嗜碱性粒细胞和中性粒细胞计数的影响。
   材料和方法:患有轻度至中度过敏性哮喘的参与者(n=64)被随机分为两组:对照组接受安慰剂胶囊,干预组接受250mg石榴提取物胶囊,每天两次(持续8周)。为了分析数据,我们使用SPSS软件(版本22)。p值的显著性水平为小于0.05。
   结果:与对照组相比,石榴提取物改善了干预组患者的临床症状,如每日呼吸短促、夜间呼吸短促和哮喘相关活动受限。此外,干预组的嗜酸性粒细胞、嗜碱性粒细胞和中性粒细胞计数显著减少。此外,通过比较两组,中性粒细胞和嗜酸性粒细胞的变化水平具有统计学意义。
   结论:石榴提取物可以改善过敏性哮喘患者的某些临床症状,减少中性粒细胞、嗜碱性粒细胞和嗜酸性粒细胞。

 
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Front Pharmacol. 2023 Jan 25;14:1109966. doi: 10.3389/fphar.2023.1109966. eCollection 2023.)

 
 
Does pomegranate extract supplementation improve the clinical symptoms of patients with allergic asthma? A double-blind, randomized, placebo-controlled trial

Seyed Ahmad Hosseini, Zainab Shateri, Farhad Abolnezhadian, Elham Maraghi, Maryam Haddadzadeh Shoushtari, Marzie Zilaee
 
Abstract
Background: Asthma essentially represents a chronic inflammatory disease that manifests as a lifelong condition with different severity throughout the life of patients with asthma. Pomegranate holds three times the antioxidant activity compared to other polyphenol-rich food sources like green tea, which may positively impact asthma.
Aim of the study: This research aimed to investigate the pomegranate supplementation influences clinical symptoms, eosinophil, basophil, and neutrophil counts in patients with allergic asthma.
Materials and Methods: Participants (n = 64) suffering from mild to moderate allergic asthma were randomly divided into two groups: The control group received placebo capsules and the intervention group received 250 mg pomegranate extract capsules twice a day (for 8 weeks). To analyze the data, we used SPSS software (version 22). The significance level of p-value was considered less than 0.05.
Results: The findings showed that the pomegranate extract improved patients' clinical symptoms like daily breath shortness, nocturnal breath shortness, and limitation of asthma-related activity in the intervention group compared to the control group. Furthermore, eosinophil, basophil, and neutrophil counts were significantly decreased in the intervention group. Also, by comparing the two groups, the levels of change in neutrophils and eosinophils were statistically significant.
Conclusion: It appears that the pomegranate extract can ameliorate some clinical symptoms and reduce neutrophils, basophils, and eosinophils in allergic asthma patients.
Clinical Trial Registration: https://www.irct.ir/trial/45612; identifier: IRCT20200205046384N1.
 


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