奶农哮喘的发病率和风险因素：AIRBAg的辅助分析
2022/11/22
摘要
背景：长期的职业性农业接触与哮喘诊断的增加有关。这项研究旨在确定奶农中哮喘的流行率和风险因素。
方法：AIRBAg是一项横断面研究，包括1203名有代表性的奶农。他们填写了一份自编的调查问卷，并进行了呼吸道健康检查。任何有喘息、呼吸困难、慢性支气管炎、慢性咳嗽或FEV1/FEV6比率<80%的参与者都会被转诊到肺科医生处。他们接受了进一步的检查，如带有可逆性测试的肺活量测定。对照组（非哮喘的奶农和非农场雇员）与每个哮喘病例的性别和年龄（±5岁）相匹配。哮喘和不同风险因素之间的比值比（OR）是用条件性多变量逻辑回归模型估计的。
结果：107名（8.9%）奶农被诊断为活动性哮喘。与对照组奶农相比，与过敏家族史（OR = 8.68；95% CI [4.26-17.69]）、湿疹个人史（OR = 3.39；95% CI [1.61-7.13]）和干草处理（OR = 5.36，95% CI [1.59-18.01]）呈正相关，与农场面积（OR = 0.92；95% CI [0.85-0.99]）和处理过的种子（OR = 0.47；95% CI [0.23-0.95]）呈负相关。与对照组的非农场雇员相比，哮喘和过敏家族史之间存在正相关（OR = 95.82，95% CI [12.55-731.47]）。
结论：奶农的活动性哮喘的发病率比在普通人群中观察到的比率要高一些，但是可以通过在农场的职业适应性来减少对空气中有机污染物的接触来控制。
Prevalence and risk factors of asthma in dairy farmers: Ancillary analysis of AIRBAg
Jouneau, S., Chapron, A., Ropars, C., Marette, S., Robert, A. M., Gouyet, T., Belleguic, C., Rochefort-Morel, C., Guillot, S., Mailloux, C., Desrues, B., Viel, J. F., & AIRBAg research group (2022)
Abstract
BACKGROUND：Prolonged occupational agricultural exposure is associated with an increase in asthma diagnosis. This study aimed to identify the prevalence and risk factors for asthma in dairy farmers.
METHODS：AIRBAg was a cross-sectional study including 1203 representative dairy farmers. They completed a self-administered questionnaire and underwent a health respiratory check-up. Referral to a pulmonologist was made for any participant with wheezing, dyspnoea, chronic bronchitis, a chronic cough or a FEV1/FEV6 ratio<80%. They underwent further examinations such as spirometry with a reversibility test. Controls (non-asthmatic dairy farmers and non-farm employees) were matched to each asthma case for sex and age (±5 years). The odds ratios (OR) between asthma and different risk factors were estimated using conditional multivariate logistic regression models.
RESULTS：Active asthma was diagnosed in 107 (8.9%) farmers. Compared with control dairy farmers, there was a positive association with family history of allergy (OR = 8.68; 95% CI [4.26-17.69]), personal history of eczema (OR = 3.39; 95% CI [1.61-7.13]), hay manipulation (OR = 5.36, 95% CI [1.59-18.01]), and a negative association with farm area (OR = 0.92; 95% CI [0.85-0.99]) and handling treated seeds (OR = 0.47; 95% CI [0.23-0.95]). Compared with control non-farm employees, there was a positive association between asthma and family history of allergy (OR = 95.82, 95% CI [12.55-731.47]).
CONCLUSION：The prevalence of active asthma in dairy farmers was somewhat higher than the rate observed in the general population but may be controlled by reducing exposure to airborne organic contaminants through occupational adaptions on farms.
背景：长期的职业性农业接触与哮喘诊断的增加有关。这项研究旨在确定奶农中哮喘的流行率和风险因素。
方法：AIRBAg是一项横断面研究，包括1203名有代表性的奶农。他们填写了一份自编的调查问卷，并进行了呼吸道健康检查。任何有喘息、呼吸困难、慢性支气管炎、慢性咳嗽或FEV1/FEV6比率<80%的参与者都会被转诊到肺科医生处。他们接受了进一步的检查，如带有可逆性测试的肺活量测定。对照组（非哮喘的奶农和非农场雇员）与每个哮喘病例的性别和年龄（±5岁）相匹配。哮喘和不同风险因素之间的比值比（OR）是用条件性多变量逻辑回归模型估计的。
结果：107名（8.9%）奶农被诊断为活动性哮喘。与对照组奶农相比，与过敏家族史（OR = 8.68；95% CI [4.26-17.69]）、湿疹个人史（OR = 3.39；95% CI [1.61-7.13]）和干草处理（OR = 5.36，95% CI [1.59-18.01]）呈正相关，与农场面积（OR = 0.92；95% CI [0.85-0.99]）和处理过的种子（OR = 0.47；95% CI [0.23-0.95]）呈负相关。与对照组的非农场雇员相比，哮喘和过敏家族史之间存在正相关（OR = 95.82，95% CI [12.55-731.47]）。
结论：奶农的活动性哮喘的发病率比在普通人群中观察到的比率要高一些，但是可以通过在农场的职业适应性来减少对空气中有机污染物的接触来控制。
(中日友好医院呼吸与危重症医学科 沈焜路 摘译 林江涛 审校)
(Environ Res. 2022 Nov; DOI: 10.1016/j.envres.2022.114145)
(Environ Res. 2022 Nov; DOI: 10.1016/j.envres.2022.114145)
Prevalence and risk factors of asthma in dairy farmers: Ancillary analysis of AIRBAg
Jouneau, S., Chapron, A., Ropars, C., Marette, S., Robert, A. M., Gouyet, T., Belleguic, C., Rochefort-Morel, C., Guillot, S., Mailloux, C., Desrues, B., Viel, J. F., & AIRBAg research group (2022)
Abstract
BACKGROUND：Prolonged occupational agricultural exposure is associated with an increase in asthma diagnosis. This study aimed to identify the prevalence and risk factors for asthma in dairy farmers.
METHODS：AIRBAg was a cross-sectional study including 1203 representative dairy farmers. They completed a self-administered questionnaire and underwent a health respiratory check-up. Referral to a pulmonologist was made for any participant with wheezing, dyspnoea, chronic bronchitis, a chronic cough or a FEV1/FEV6 ratio<80%. They underwent further examinations such as spirometry with a reversibility test. Controls (non-asthmatic dairy farmers and non-farm employees) were matched to each asthma case for sex and age (±5 years). The odds ratios (OR) between asthma and different risk factors were estimated using conditional multivariate logistic regression models.
RESULTS：Active asthma was diagnosed in 107 (8.9%) farmers. Compared with control dairy farmers, there was a positive association with family history of allergy (OR = 8.68; 95% CI [4.26-17.69]), personal history of eczema (OR = 3.39; 95% CI [1.61-7.13]), hay manipulation (OR = 5.36, 95% CI [1.59-18.01]), and a negative association with farm area (OR = 0.92; 95% CI [0.85-0.99]) and handling treated seeds (OR = 0.47; 95% CI [0.23-0.95]). Compared with control non-farm employees, there was a positive association between asthma and family history of allergy (OR = 95.82, 95% CI [12.55-731.47]).
CONCLUSION：The prevalence of active asthma in dairy farmers was somewhat higher than the rate observed in the general population but may be controlled by reducing exposure to airborne organic contaminants through occupational adaptions on farms.
上一篇：
没有了
下一篇：
没有了
