嗜酸粒细胞性哮喘
2020/09/17
摘要
人们对哮喘内型的认识不断演变的，目前还没有公认的标准来定义内型。高TH2内型可能有过敏或非过敏基础，其典型特征是具有一定程度的嗜酸粒细胞性气道炎症。无偏倚聚类分析已经确定了以TH2炎症为特征的与嗜酸粒细胞炎症内型相关的儿童和成人表型。阿司匹林引起的呼吸系统疾病加重也一直被认为是一种独特的哮喘表型。本文表述了通过生物标志物来确定这些疾病类型，并以此来选择有针对性的治疗方式，特别是应用在需要生物制剂治疗的严重疾病。
Eosinophilic Asthma.
Ryan K Nelson ,Andrew Bush ,Jeffrey Stokes ,Parameswaran Nair ,Praveen Akuthota.
Abstract
Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The TH2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by TH2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined.
人们对哮喘内型的认识不断演变的，目前还没有公认的标准来定义内型。高TH2内型可能有过敏或非过敏基础，其典型特征是具有一定程度的嗜酸粒细胞性气道炎症。无偏倚聚类分析已经确定了以TH2炎症为特征的与嗜酸粒细胞炎症内型相关的儿童和成人表型。阿司匹林引起的呼吸系统疾病加重也一直被认为是一种独特的哮喘表型。本文表述了通过生物标志物来确定这些疾病类型，并以此来选择有针对性的治疗方式，特别是应用在需要生物制剂治疗的严重疾病。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(J Allergy Clin Immunol Pract,2020 Feb;8(2):465-473. doi: 10.1016/j.jaip.2019.11.024. Epub 2019 Nov 28.)
(J Allergy Clin Immunol Pract,2020 Feb;8(2):465-473. doi: 10.1016/j.jaip.2019.11.024. Epub 2019 Nov 28.)
Eosinophilic Asthma.
Ryan K Nelson ,Andrew Bush ,Jeffrey Stokes ,Parameswaran Nair ,Praveen Akuthota.
Abstract
Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The TH2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by TH2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined.
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欧洲过敏和气道疾病研究和教育论坛关于治疗伴或不伴哮喘的慢性鼻窦炎鼻息肉的生物制剂的共识
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哮喘：从免疫机制到精准医学
