成人哮喘与情感特征：一项遗传信息研究
2019/12/03
摘要
抑郁、焦虑和高度神经质（情感特征）常与哮喘共同发病。情感特征与哮喘之间的因果关系很难确定，但是，他们之间可能有一个共同的潜在途径归因于共享遗传因素。我们旨在确定哮喘与每种情感特征之间是否存在共同的遗传易感性。
瑞典双胞胎登记中心的一个成人队列接受了基于问卷的健康评估（n=23693）和基因分型（n=15908）。首先，以问卷调查为基础，探讨哮喘与情感特征之间的关系。接下来是遗传分析：a）情感特征的多基因风险评分（polygenic risk scores，PRS）被用作队列中哮喘的预测因子，b）英国生物样本库的全基因组关联结果用于连锁不平衡评分回归（LDSC），以量化哮喘与情感特征之间的遗传相关性。分析发现，基于问卷调查的哮喘与情感特征之间存在相关性（重度抑郁症：OR为1.67，95% CI：1.50-1.86；焦虑：OR为1.45， 95% CI：1.30-1.61；高度神经质OR为1.60， 95% CI：1.40-1.92）。神经质的遗传易感性解释了哮喘存在剂量效应的变异；也就是说，神经质PRS四分位数最高的研究参与者比四分位数最低的参与者更可能患有哮喘（OR为1.37，95% CI：1.17-1.61）。抑郁与哮喘之间存在遗传相关性（rg＝0.17），而非焦虑或神经质。
我们的结论是，观察到哮喘与情感特征之间的共存可能部分源于哮喘与抑郁症（LDSC）以及神经质（PRS）之间共有遗传的影响，而非焦虑。
Asthma and affective traits in adults: a genetically informative study.
Lehto K, Pedersen NL, Almqvist C, Lu Y, Brew BK.
Eur Respir J. 2019;53(5). pii: 1802142.
ABSTRACT
Depression, anxiety and high neuroticism (affective traits) are often comorbid with asthma. A causal direction between the affective traits and asthma is difficult to determine, however, there may be a common underlying pathway attributable to shared genetic factors. Our aim was to determine whether a common genetic susceptibility exists for asthma and each of the affective traits.
An adult cohort from the Swedish Twin Registry underwent questionnaire-based health assessments (n=23693) and genotyping (n=15908). Firstly, questionnaire-based associations between asthma and affective traits were explored. This was followed by genetic analyses: a) polygenic risk scores (PRS) for affective traits were used as predictors of asthma in the cohort, and b) genome-wide association results from UK Biobank were used in linkage-disequilibrium score regression (LDSC) to quantify genetic correlations between asthma and affective traits. Analyses found associations between questionnaire-based asthma and affective traits (odds ratio (OR) 1.67 95%CI 1.50-1.86 major depression, OR 1.45 95% CI 1.30-1.61 anxiety, and OR 1.60 95%CI 1.40-1.82 high neuroticism). Genetic susceptibility for neuroticism explained the variance in asthma with a dose response effect; that is, study participants in the highest neuroticism PRS quartile were more likely to have asthma than those in the lowest quartile (OR 1.37, 95%CI 1.17-1.61). Genetic correlations were found between depression and asthma (rg= 0.17), but not for anxiety or neuroticism.
We conclude that the observed comorbidity between asthma and the affective traits may in part be due to shared genetic influences between asthma and depression (LDSC) and neuroticism (PRS), but not anxiety.
抑郁、焦虑和高度神经质（情感特征）常与哮喘共同发病。情感特征与哮喘之间的因果关系很难确定，但是，他们之间可能有一个共同的潜在途径归因于共享遗传因素。我们旨在确定哮喘与每种情感特征之间是否存在共同的遗传易感性。
瑞典双胞胎登记中心的一个成人队列接受了基于问卷的健康评估（n=23693）和基因分型（n=15908）。首先，以问卷调查为基础，探讨哮喘与情感特征之间的关系。接下来是遗传分析：a）情感特征的多基因风险评分（polygenic risk scores，PRS）被用作队列中哮喘的预测因子，b）英国生物样本库的全基因组关联结果用于连锁不平衡评分回归（LDSC），以量化哮喘与情感特征之间的遗传相关性。分析发现，基于问卷调查的哮喘与情感特征之间存在相关性（重度抑郁症：OR为1.67，95% CI：1.50-1.86；焦虑：OR为1.45， 95% CI：1.30-1.61；高度神经质OR为1.60， 95% CI：1.40-1.92）。神经质的遗传易感性解释了哮喘存在剂量效应的变异；也就是说，神经质PRS四分位数最高的研究参与者比四分位数最低的参与者更可能患有哮喘（OR为1.37，95% CI：1.17-1.61）。抑郁与哮喘之间存在遗传相关性（rg＝0.17），而非焦虑或神经质。
我们的结论是，观察到哮喘与情感特征之间的共存可能部分源于哮喘与抑郁症（LDSC）以及神经质（PRS）之间共有遗传的影响，而非焦虑。
(韩宇宇1 张红萍1 王刚2 四川大学华西医院中西医结合科呼吸病组 610041 摘译)
（Eur Respir J. 2019;53(5). pii: 1802142.）
（Eur Respir J. 2019;53(5). pii: 1802142.）
Asthma and affective traits in adults: a genetically informative study.
Lehto K, Pedersen NL, Almqvist C, Lu Y, Brew BK.
Eur Respir J. 2019;53(5). pii: 1802142.
ABSTRACT
Depression, anxiety and high neuroticism (affective traits) are often comorbid with asthma. A causal direction between the affective traits and asthma is difficult to determine, however, there may be a common underlying pathway attributable to shared genetic factors. Our aim was to determine whether a common genetic susceptibility exists for asthma and each of the affective traits.
An adult cohort from the Swedish Twin Registry underwent questionnaire-based health assessments (n=23693) and genotyping (n=15908). Firstly, questionnaire-based associations between asthma and affective traits were explored. This was followed by genetic analyses: a) polygenic risk scores (PRS) for affective traits were used as predictors of asthma in the cohort, and b) genome-wide association results from UK Biobank were used in linkage-disequilibrium score regression (LDSC) to quantify genetic correlations between asthma and affective traits. Analyses found associations between questionnaire-based asthma and affective traits (odds ratio (OR) 1.67 95%CI 1.50-1.86 major depression, OR 1.45 95% CI 1.30-1.61 anxiety, and OR 1.60 95%CI 1.40-1.82 high neuroticism). Genetic susceptibility for neuroticism explained the variance in asthma with a dose response effect; that is, study participants in the highest neuroticism PRS quartile were more likely to have asthma than those in the lowest quartile (OR 1.37, 95%CI 1.17-1.61). Genetic correlations were found between depression and asthma (rg= 0.17), but not for anxiety or neuroticism.
We conclude that the observed comorbidity between asthma and the affective traits may in part be due to shared genetic influences between asthma and depression (LDSC) and neuroticism (PRS), but not anxiety.
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妊娠期哮喘加重对哮喘妇女的影响：一项基于人群的队列研究
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一项儿童和青少年严重哮喘的纵向研究
