转胶蛋白-2在癌症和哮喘中的生化和临床意义
2019/09/09
摘要
转胶蛋白-2被认为是一种肌动蛋白结合蛋白，可诱导肌动蛋白凝胶化并调节肌动蛋白骨架。然而，最近研究显示转胶蛋白-2作为细胞外金属硫蛋白-2的受体来松弛气道平滑肌细胞的肌球蛋白骨架。从临床角度来看，这些结果支持转胶蛋白-2可作为有希望的疾病治疗靶点，如癌症和哮喘等。 抑制转胶蛋白-2可防止肌动蛋白凝胶化，从而防止癌细胞增殖、侵袭和转移。 相反，用特异性激动剂激活转胶蛋白-2可以松弛气道平滑肌，降低哮喘的肺阻力。 本文中，我们综述了有关转胶蛋白-2生化特性的新研究，并讨论了它们对免疫、致癌和呼吸系统疾病治疗的临床意义。
Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.
Yin LM, Ulloa L, Yang YQ.
Abstract
Transgelin-2 has been regarded as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. However, transgelin-2 has recently been shown to relax the myosin cytoskeleton of the airway smooth muscle cells by acting as a receptor for extracellular metallothionein-2. From a clinical perspective, these results support transgelin-2 as a promising therapeutic target for diseases such as cancer and asthma. The inhibition of transgelin-2 prevents actin gelation and thereby cancer cell proliferation, invasion, and metastasis. Conversely, the activation of transgelin-2 with specific agonists relaxes airway smooth muscles and reduces pulmonary resistance in asthma. Here, we review new studies on the biochemical properties of transgelin-2 and discuss their clinical implications for the treatment of immune, oncogenic, and respiratory disorders.
转胶蛋白-2被认为是一种肌动蛋白结合蛋白，可诱导肌动蛋白凝胶化并调节肌动蛋白骨架。然而，最近研究显示转胶蛋白-2作为细胞外金属硫蛋白-2的受体来松弛气道平滑肌细胞的肌球蛋白骨架。从临床角度来看，这些结果支持转胶蛋白-2可作为有希望的疾病治疗靶点，如癌症和哮喘等。 抑制转胶蛋白-2可防止肌动蛋白凝胶化，从而防止癌细胞增殖、侵袭和转移。 相反，用特异性激动剂激活转胶蛋白-2可以松弛气道平滑肌，降低哮喘的肺阻力。 本文中，我们综述了有关转胶蛋白-2生化特性的新研究，并讨论了它们对免疫、致癌和呼吸系统疾病治疗的临床意义。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Trends Biochem Sci. 2019 Jun 27. pii: S0968-0004(19)30118-5. doi: 10.1016/j.tibs.2019.05.004.)
(Trends Biochem Sci. 2019 Jun 27. pii: S0968-0004(19)30118-5. doi: 10.1016/j.tibs.2019.05.004.)
Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma.
Yin LM, Ulloa L, Yang YQ.
Abstract
Transgelin-2 has been regarded as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. However, transgelin-2 has recently been shown to relax the myosin cytoskeleton of the airway smooth muscle cells by acting as a receptor for extracellular metallothionein-2. From a clinical perspective, these results support transgelin-2 as a promising therapeutic target for diseases such as cancer and asthma. The inhibition of transgelin-2 prevents actin gelation and thereby cancer cell proliferation, invasion, and metastasis. Conversely, the activation of transgelin-2 with specific agonists relaxes airway smooth muscles and reduces pulmonary resistance in asthma. Here, we review new studies on the biochemical properties of transgelin-2 and discuss their clinical implications for the treatment of immune, oncogenic, and respiratory disorders.
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