中国大陆哮喘的流行与危险因素：CARE研究
2018/09/10
摘要
背景：目前中国关于哮喘流行情况的人群原始数据较为有限。中国哮喘与危险因素流行病学（CARE）调查旨在了解中国大陆哮喘的流行情况及危险因素。
目的：CARE调查旨在描绘中国大陆青少年（年龄> 14岁）和成人哮喘的流行情况及危险因素。
方法：该调查于2010年2月至2012年8月在中国大陆七个地区的八个省/市进行。本次调查通过多阶段整群随机抽样方法招募年龄大于14岁的居民。哮喘诊断基于病史和肺功能检查。多变量逻辑回归用于分析哮喘的危险因素。
结果：该研究纳入了164215名受试者（男性，79692人 [48.53％];女性，84523人 [51.47％]），其中2034人（1.24％）为哮喘患者。在所有哮喘患者中，新诊断出521例（25.61％）。单因素回归分析显示哮喘的危险因素包括吸烟，哮喘患者一级亲属，过敏性鼻炎，慢性支气管炎，COPD，花粉症，过敏性肺炎，伴发过敏性疾病，BMI和饲养宠物。多变量logistic回归分析表明哮喘危险因素包括女性，年龄分层，吸烟，患有哮喘或花粉症患者的一级亲属，伴过敏性鼻炎，湿疹或胃食管反流病。
结论：我们推测，在过去10年中，中国大陆年龄大于14岁的人群中哮喘患病率正在增加。许多哮喘危险因素被发现。在我们未来的工作中，哮喘的危险因素将得到进一步阐明。
临床意义：我们的CARE研究强调，中国大陆哮喘的流行情况应得到更多关注。
Prevalence and risk factors of asthma in mainland China: The CARE study.
Lin J, Wang W, Chen P, Zhou X, Wan H, Yin K, Ma L, Wu C, Li J, Liu C, Su N, Liu G, Xie H, Tang W, Huang M, Chen Y, Liu Y, Song L, Chen X, Zhang Y, Li W, Sun L.
Abstract
BACKGROUND:There are limited population based data on the prevalence of asthma in China. The China Asthma and Risk factors Epidemiologic (CARE) survey was designed to understand the prevalence and risk factors for asthma in mainland China.
OBJECTIVE:There are limited population based data on the prevalence of asthma in China. The China Asthma and Risk factors Epidemiologic (CARE) survey was designed to understand the prevalence and risk factors for asthma in mainland China.
METHODS:The survey was performed between February 2010 and August 2012 in eight provinces/cities of seven areas in mainland China. The inhabitants (age, >14 years) recruited in this survey were through multi-stage cluster random sampling. Asthma diagnosis was based on medical history and lung function tests. Multivariable logistic regression was used to analyzed the risk factors for asthma.
RESULTS:The study included 164 215 subjects (men, 79 692 [48.53%]; women, 84 523 [51.47%]). 2034 (1.24%) were asthmatic patients. Among all asthmatic patients, 521 (25.61%) were newly diagnosed. Univariable regression analysis showed that risk factors for asthma included smoking, first-degree relatives with asthma, allergic rhinitis, chronic bronchitis, COPD, pollinosis, allergic pneumonia, concomitant allergic diseases, BMI and raising pets. Multivariable logistic regression indicated that asthma risk factors included women, age stratification, smoking, first-degree relatives suffering from asthma or pollinosis, combined with allergic rhinitis, eczema or GERD.
CONCLUSIONS:We speculated that the prevalence of asthma is increasing in mainland China among individuals aged >14 years in the past 10 years. A number of risk factors were identified. The risk factors of asthma would be further elucidated in our future work.
CLINICAL IMPLICATIONS:Our CARE study highlights that asthma epidemic in mainland China should be paid more attention.
背景：目前中国关于哮喘流行情况的人群原始数据较为有限。中国哮喘与危险因素流行病学（CARE）调查旨在了解中国大陆哮喘的流行情况及危险因素。
目的：CARE调查旨在描绘中国大陆青少年（年龄> 14岁）和成人哮喘的流行情况及危险因素。
方法：该调查于2010年2月至2012年8月在中国大陆七个地区的八个省/市进行。本次调查通过多阶段整群随机抽样方法招募年龄大于14岁的居民。哮喘诊断基于病史和肺功能检查。多变量逻辑回归用于分析哮喘的危险因素。
结果：该研究纳入了164215名受试者（男性，79692人 [48.53％];女性，84523人 [51.47％]），其中2034人（1.24％）为哮喘患者。在所有哮喘患者中，新诊断出521例（25.61％）。单因素回归分析显示哮喘的危险因素包括吸烟，哮喘患者一级亲属，过敏性鼻炎，慢性支气管炎，COPD，花粉症，过敏性肺炎，伴发过敏性疾病，BMI和饲养宠物。多变量logistic回归分析表明哮喘危险因素包括女性，年龄分层，吸烟，患有哮喘或花粉症患者的一级亲属，伴过敏性鼻炎，湿疹或胃食管反流病。
结论：我们推测，在过去10年中，中国大陆年龄大于14岁的人群中哮喘患病率正在增加。许多哮喘危险因素被发现。在我们未来的工作中，哮喘的危险因素将得到进一步阐明。
临床意义：我们的CARE研究强调，中国大陆哮喘的流行情况应得到更多关注。
(中日友好医院呼吸与危重症医学科 顾宪民 摘译 林江涛 审校)
(Respir Med. 2018 Apr;137:48-54.)
(Respir Med. 2018 Apr;137:48-54.)
Prevalence and risk factors of asthma in mainland China: The CARE study.
Lin J, Wang W, Chen P, Zhou X, Wan H, Yin K, Ma L, Wu C, Li J, Liu C, Su N, Liu G, Xie H, Tang W, Huang M, Chen Y, Liu Y, Song L, Chen X, Zhang Y, Li W, Sun L.
Abstract
BACKGROUND:There are limited population based data on the prevalence of asthma in China. The China Asthma and Risk factors Epidemiologic (CARE) survey was designed to understand the prevalence and risk factors for asthma in mainland China.
OBJECTIVE:There are limited population based data on the prevalence of asthma in China. The China Asthma and Risk factors Epidemiologic (CARE) survey was designed to understand the prevalence and risk factors for asthma in mainland China.
METHODS:The survey was performed between February 2010 and August 2012 in eight provinces/cities of seven areas in mainland China. The inhabitants (age, >14 years) recruited in this survey were through multi-stage cluster random sampling. Asthma diagnosis was based on medical history and lung function tests. Multivariable logistic regression was used to analyzed the risk factors for asthma.
RESULTS:The study included 164 215 subjects (men, 79 692 [48.53%]; women, 84 523 [51.47%]). 2034 (1.24%) were asthmatic patients. Among all asthmatic patients, 521 (25.61%) were newly diagnosed. Univariable regression analysis showed that risk factors for asthma included smoking, first-degree relatives with asthma, allergic rhinitis, chronic bronchitis, COPD, pollinosis, allergic pneumonia, concomitant allergic diseases, BMI and raising pets. Multivariable logistic regression indicated that asthma risk factors included women, age stratification, smoking, first-degree relatives suffering from asthma or pollinosis, combined with allergic rhinitis, eczema or GERD.
CONCLUSIONS:We speculated that the prevalence of asthma is increasing in mainland China among individuals aged >14 years in the past 10 years. A number of risk factors were identified. The risk factors of asthma would be further elucidated in our future work.
CLINICAL IMPLICATIONS:Our CARE study highlights that asthma epidemic in mainland China should be paid more attention.
上一篇：
青春期的年龄与哮喘风险：一项孟德尔随机化研究
下一篇：
1999-2015年美国与哮喘相关的死亡率:一项死亡相关的多因素分析
