在哮喘和慢性阻塞性肺疾病中microRNA表达差异的初步研究
2016/10/09
摘要
简介：近年来，哮喘和慢性阻塞性肺疾病（COPD）相关的发病率呈逐年上升的增长。哮喘和慢性阻塞性肺病都是炎症性疾病。对阻塞性肺疾病发展的病理机制越来有兴趣似乎是完全有道理的。最近的研究试图确定肺疾病的发病机制与microRNA之间的关系。
目的:探讨患者与健康受试者相比，microRNA在支气管哮喘和慢性阻塞性肺疾病患者血清中的表达。.
材料与方法：在我们的研究中，在初步阶段，我们比较了在哮喘和慢性阻塞性肺疾病患者与健康对照组受试者中miRNA的表达。
结果：哮喘患者和COPD患者与对照组相比，hsa-miRNA-224，hsa-miRNA-339-5p，和hsa-miRNA-382表现出显著差异。
结论：在哮喘和慢性阻塞性肺疾病患者血清中特异性micro-RNA的表达具有差异，这些小的非编码RNA在这些疾病的途径中起着重要的作用。因此，我们预计将在下一步研究中增加研究组的大小和区别。
关键词;哮喘；慢性阻塞性肺疾病；microRNA；血清
（杨冬 审校）
Postepy Dermatol Alergol. 2016 Aug;33(4):276-80. doi: 10.5114/ada.2016.61603. Epub 2016 Aug 16.
Preliminary studies: differences in microRNA expression in asthma and chronic obstructive pulmonary disease.
Pietrusińska M1, Pająk A1, Górski P1, Kuna P2, Szemraj J3, Goździńska-Nielepkowicz A4, Pietras T5.
Author information
Abstract
INTRODUCTION:The asthma- and chronic obstructive pulmonary disease (COPD)-related morbidity has been increasing during the recent years. Both asthma and COPD are diseases of inflammatory etiology. The increasing interest in the pathomechanisms involved in the development of obstructive pulmonary diseases seems to be fully justified. Recent research has attempted to determine the associations of microRNA with the pathogenesis of pulmonary diseases.
AIM:To assess the expression of microRNA in the blood sera of patients diagnosed with bronchial asthma and chronic obstructive pulmonary disease in comparison with healthy subjects.
MATERIAL AND METHODS:In our study, at the preliminary stage, we compared the expression of miRNA in the groups of patients with asthmaand COPD versus the control group of healthy subjects.
RESULTS:A significant difference in hsa-miRNA-224, hsa-miRNA-339-5p, hsa-miRNA-382 in patients with asthma and COPD as compared with the controls was noted.
CONCLUSIONS:With such difference of expression of specific micro-RNA in serum of patient with asthma and COPD, those small non-coding RNA has to play a significant role in those diseases pathway. Therefore we expect to increase the size and differentation of the study groups in next studies.
KEYWORDS:asthma; chronic obstructive pulmonary disease; microRNA; serum
Postepy Dermatol Alergol. 2016 Aug;33(4):276-80. doi: 10.5114/ada.2016.61603. Epub 2016 Aug 16.
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