哮喘联盟

   摘要
   背景：高血压和吸烟是动脉瘤形成或破裂的危险因素。我们旨在判定前交通动脉(AcoA)瘤患者与高血压或吸烟相关的动脉瘤形态学差异。
   方法：研究从电子病历系统中纳入2007年12月至2015年2月间的574例患有AcoA动脉瘤的连续的患者。我们从中提取出仅有高血压史、仅有吸烟史，无高血压和吸烟以及既有高血压又吸烟的患者数据。使用CTA图像重建来重新测量动脉瘤的形态学参数。使用多变量回归分析来判断高血压或吸烟患者动脉瘤的形态学差异。
   结果：研究共纳入495例患有单个AcoA动脉瘤的患者。在不同组患者中年龄、性别、血管大小、动脉瘤大小和高度，大小比率、A1段形态以及动脉瘤的形状均有显著的差异。与那些没有高血压的非吸烟者相比，更大的动脉瘤更多发生在仅吸烟的患者中(校正后OR, 1.19; 95% CI, 1.04-1.36; P=0.012)。患有高血压且同时吸烟的患者的动脉瘤大小通常比那些仅仅患高血压的患者的动脉瘤更大(校正后 OR, 0.89; 95% CI, 0.79-0.99; P=0.040)。吸烟的患者和仅仅患高血压的患者之间年龄，性别，动脉瘤的形态学均存在显著差异。
   结论：与其他的动脉瘤形态学相比，动脉瘤的大小是ACoA动脉瘤患者中的一个与吸烟相关的独立形态学参数。吸烟可能是与动脉瘤增大相关的的独立因素，并且ACoA动脉瘤患者应当戒烟。

 

（苏欣 审校）
WorldNeurosurg.2015Dec27.pii:S1878-8750(15)01717-9.doi:10.1016/j.wneu.2015.11.094. [Epub ahead of print]

 

Smoking associated with increased aneurysm size in patients with anterior communicating artery aneurysms.
 

Xia N1, Liu Y1, Zhong M2, Zhuge Q2, Fan L2, Chen W1, Yang Y3, Zhao B4.
 

Abstract
BACKGROUND:Hypertension and smoking are risk factors for aneurysm formation or rupture. We aimed to identify differences in aneurysm morphologies associated with hypertension or smoking in patients with anterior communicating artery (AcoA) aneurysms.
METHODS:Between December 2007 and February 2015, 574 consecutive patients with AcoA aneurysms were identified from the Electronic Medical Record System. We extracted data on histories of hypertension alone, smoking alone, non-hypertension and non-smoking and both hypertension and smoking. The Morphological parameters of aneurysms were re-measured using CTA image reconstruction. Multivariate logistic regression analyses were used to determine the differences in morphologies in patients with hypertension or who smoked.
RESULTS:In the study 495 patients with single AcoA aneurysm were included. Age, gender, vessel size, aneurysm size and height, size ratio, A1 segment configuration, and aneurysm shape were significantly different among the groups. A larger aneurysm more often occurred in patients who only smoked compared with those without hypertension who did not smoke (adjusted OR, 1.19; 95% CI, 1.04-1.36; P=0.012). Patients with hypertension who also smoked more commonly had a larger aneurysm size than those with hypertension alone (adjusted OR, 0.89; 95% CI, 0.79-0.99; P=0.040). There were significant differences in age, sex, aneurysm morphology between the smoking patients and those with hypertension alone.
CONCLUSION:Aneurysm size was an independent morphological parameter associated with smoking in patients with ACoA aneurysms compared with other aneurysm morphologies. Smoking may be independently associated with increased aneurysm size and should be quitted in patients with AcoA aneurysms.
 

WorldNeurosurg.2015Dec27.pii:S1878-8750(15)01717-9.doi:10.1016/j.wneu.2015.11.094. [Epub ahead of print]