哮喘联盟

   摘要
   健康饮食习惯对于哮喘控制的获益，尚缺乏严谨研究。我们纳入90例确诊的控制不佳且低质量饮食（终止高血压膳食疗法(DASH)评分<6）的哮喘患者，将其随机分为DASH行为干预组(n=46)和常规护理组(n=44)，进行为期6个月的研究。意向处理分析使用重复测量混合模型。参与者为中年，女性占67%，且涉及多个民族。与对照组相比，干预组6个月时的DASH评分有所提高（平均改变(95% CI)为0.6 (0, 1.1) vs -0.3 (-0.8, 0.2)；差异为0.8 (0.2, 1.5)），主要结果即哮喘控制问卷得分有所提高（-0.2 (-0.5, 0) vs 0 (-0.3, 0.3); 差异为-0.2 (-0.5, 0.1)）。迷你哮喘生活品质问卷总体得分和子域得分的改变的平均组间差异持续支持干预组：总体0.4 (95% CI 0, 0.8)、症状0.5 (0, 0.9)、环境0.4 (-0.1, 1.0)、情感0.4 (-0.2, 0.9)以及活动0.3 (0, 0.7)。这些差异较小，但是具有潜在的临床意义。DASH行为干预改善了饮食质量，对于哮喘控制不佳的成人患者来说，能够更好地控制哮喘和改善功能状态。一个全面的功效试验是十分必要的。


 

（苏欣 审校）
Eur Respir J. 2015 Oct 22. pii: ERJ-00591-2015. doi: 10.1183/13993003.00591-2015. [Epub ahead of print]

Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma.
 

Ma J1, Strub P2, Lv N3, Xiao L3, Camargo CA Jr4, Buist AS5, Lavori PW6, Wilson SR7, Nadeau KC8, Rosas LG7.
 

Abstract
Rigorous research on the benefit of healthy eating patterns for asthma control is lacking.We randomised 90 adults with objectively confirmed uncontrolled asthma and a low-quality diet (Dietary Approaches to Stop Hypertension (DASH) scores <6 out of 9) to a 6-month DASH behavioural intervention (n=46) or usual-care control (n=44). Intention-to-treat analyses used repeated-measures mixed models.Participants were middle-aged, 67% female and multiethnic. Compared with controls, intervention participants improved on DASH scores (mean change (95% CI) 0.6 (0, 1.1) versus -0.3 (-0.8, 0.2); difference 0.8 (0.2, 1.5)) and the primary outcome, Asthma Control Questionnaire scores (-0.2 (-0.5, 0) versus 0 (-0.3, 0.3); difference -0.2 (-0.5, 0.1)) at 6 months. The mean group differences in changes in Mini Asthma Quality of Life Questionnaire overall and subdomain scores consistently favoured the intervention over the control group: overall 0.4 (95% CI 0, 0.8), symptoms 0.5 (0, 0.9), environment 0.4 (-0.1, 1.0), emotions 0.4 (-0.2, 0.9) and activities 0.3 (0, 0.7). These differences were modest, but potentially clinical significant. The DASH behavioural intervention improved diet quality with promising clinical benefits for better asthma control and functional status among adults with uncontrolled asthma. A full-scale efficacy trial is warranted.
 

Eur Respir J. 2015 Oct 22. pii: ERJ-00591-2015. doi: 10.1183/13993003.00591-2015. [Epub ahead of print]