哮喘联盟

   摘要
   慢性阻塞性肺疾病（COPD）的自然病程经常通过1秒用力呼气容积（FEV1）随时间的改变进行描述，因为这样考虑到了促进FEV1下降从而导致COPD发展的危险因素。从流行病学研究中，我们已经发现多种重要的危险因素，如吸烟、生物量暴露和职业暴露，但是我们也了解到不依赖于暴露的可能促进FEV1降低的其他因素，如慢性支气管炎、气道高反应性和哮喘。此外，我们逐渐开始更好地将早期生活事件与成年时的疾病风险联系起来。虽然更复杂，但是我们现在对于COPD的理解已经从简单的吸烟导致肺损伤到取得了很大进展。

 

（杨冬 审校）
Respirology. 2015 Jul 15.doi: 10.1111/resp.12589. [Epub ahead of print]


 

Natural history of COPD: Focusing on change in FEV1.
 

Vestbo J1, Lange P2,3.
 

Abstract
The natural history of chronic obstructive pulmonary disease (COPD) is usually described with a focus on change in forced expiratory volume in 1 s (FEV1 ) over time as this allows for exploration of risk factors for an accelerated decline-and thus of developing COPD. From epidemiological studies we have recognized important risk factors such as smoking, exposure to biomass and occupational exposures, but we have also learnt about features such as chronic bronchitis, airway hyper-responsiveness and asthma that seem to accelerate decline in FEV1 independent of exposures. In addition we are gradually beginning to better link early life events to subsequent risk of disease in adulthood. Although more complicated, our current understanding of COPD has come a long way from being a simple image of smoking leading to poor lungs.
 

Respirology. 2015 Jul 15.doi: 10.1111/resp.12589. [Epub ahead of print]