鼻炎与支气管哮喘发病率和严重程度之间的关系
2022/05/17
摘要
背景：同一患者常同时罹患支气管哮喘和鼻炎。尽管已有作者观察到鼻炎患者支气管哮喘患病率更高，且/或更严重，但这一观点并未统一，仍存在争议。
目的：本研究旨在描述儿童和青少年鼻炎的患病率，并分析其与支气管哮喘患病率的关系。
方法：本研究采用国际儿童支气管哮喘和过敏研究 (ISAAC) 的方法学进行多中心研究。本研究的目标人群是来自加利西亚6个主要医疗卫生区（190万居民）的所有6-7岁和13-14的学龄期儿童。本研究随机选择学校，并纳入所有目标年龄范围内的儿童都。采用多元逻辑回归，并根据父母吸烟习惯、母亲教育水平、猫狗接触情况和肥胖对结果进行校正，获得学龄期儿童支气管哮喘症状与鼻炎患病率之间的校正患病率优势比（OR）。
结果：本研究最终获得有效问卷21420份。鼻炎与两个年龄组支气管哮喘患病率显著增加相关。最高患病率OR值为6-7岁亚组中的运动诱发哮喘（EIA）与近期鼻结膜炎（11.375）以及同组运动诱发哮喘（EIA）与近期鼻炎（9.807）。 EIA 和重症哮喘之间的患病率OR较高。
结论：儿童和青少年鼻炎与支气管哮喘的患病率和严重程度相关。
Association of rhinitis with asthma prevalence and severity
Acevedo-Prado A, Seoane-Pillado T, López-Silvarrey-Varela A, Salgado FJ, Cruz MJ, Faraldo-Garcia A, Nieto-Fontarigo JJ, Pértega-Díaz S, Sanchez-Lastres J, San-José-González MA, Bamonde-Rodríguez L, Garnelo-Suárez L, Pérez-Castro T, Sampedro-Campos M, Gonzalez-Barcala FJ
Abstract
BACKGROUND:Asthma and rhinitis often co-exist in the same patient. Although some authors observed a higher prevalence and/or greater severity of asthma in patients with rhinitis, this view is not homogeneous and the debate continues.
OBJECTIVE:The aim of our study is to describe the prevalence of rhinitis in children and adolescents and to analyse their relationship with the prevalence of asthma.
METHODS:A multicentre study was conducted using the methodology of the International Study of Asthma and Allergies in Childhood (ISAAC). The target population of the study was all those school children aged 6–7 and 13–14 years from 6 of the main health catchment areas of Galicia (1.9 million inhabitants). The schools required were randomly selected, and all children in the targeted age ranges were included. Multiple logistic regression was used to obtain adjusted prevalence odds ratios (OR) between asthma symptoms of the schoolchildren and rhinitis prevalence. The results were adjusted for parental smoking habits, maternal education level, cat and dog exposure, and obesity.
RESULTS:A total of 21,420 valid questionnaires were finally obtained. Rhinitis was associated with a significant increase in the prevalence of asthma in both age groups. The highest OR were 11.375 for exercise induced asthma (EIA) for children with recent rhinoconjunctivitis and 9.807 for children with recent rhinitis in 6–7 years old group. The prevalence OR’s are higher in EIA and severe asthmatics.
CONCLUSIONS:Rhinitis in children and adolescents is associated with a higher prevalence and severity of asthma.
背景：同一患者常同时罹患支气管哮喘和鼻炎。尽管已有作者观察到鼻炎患者支气管哮喘患病率更高，且/或更严重，但这一观点并未统一，仍存在争议。
目的：本研究旨在描述儿童和青少年鼻炎的患病率，并分析其与支气管哮喘患病率的关系。
方法：本研究采用国际儿童支气管哮喘和过敏研究 (ISAAC) 的方法学进行多中心研究。本研究的目标人群是来自加利西亚6个主要医疗卫生区（190万居民）的所有6-7岁和13-14的学龄期儿童。本研究随机选择学校，并纳入所有目标年龄范围内的儿童都。采用多元逻辑回归，并根据父母吸烟习惯、母亲教育水平、猫狗接触情况和肥胖对结果进行校正，获得学龄期儿童支气管哮喘症状与鼻炎患病率之间的校正患病率优势比（OR）。
结果：本研究最终获得有效问卷21420份。鼻炎与两个年龄组支气管哮喘患病率显著增加相关。最高患病率OR值为6-7岁亚组中的运动诱发哮喘（EIA）与近期鼻结膜炎（11.375）以及同组运动诱发哮喘（EIA）与近期鼻炎（9.807）。 EIA 和重症哮喘之间的患病率OR较高。
结论：儿童和青少年鼻炎与支气管哮喘的患病率和严重程度相关。
(中日友好医院呼吸与危重症医学科 张婧媛 摘译 林江涛 审校)
(Sci Rep. 2022 Apr 16;12(1):6389. doi: 10.1038/s41598-022-10448-w.)
(Sci Rep. 2022 Apr 16;12(1):6389. doi: 10.1038/s41598-022-10448-w.)
Association of rhinitis with asthma prevalence and severity
Acevedo-Prado A, Seoane-Pillado T, López-Silvarrey-Varela A, Salgado FJ, Cruz MJ, Faraldo-Garcia A, Nieto-Fontarigo JJ, Pértega-Díaz S, Sanchez-Lastres J, San-José-González MA, Bamonde-Rodríguez L, Garnelo-Suárez L, Pérez-Castro T, Sampedro-Campos M, Gonzalez-Barcala FJ
Abstract
BACKGROUND:Asthma and rhinitis often co-exist in the same patient. Although some authors observed a higher prevalence and/or greater severity of asthma in patients with rhinitis, this view is not homogeneous and the debate continues.
OBJECTIVE:The aim of our study is to describe the prevalence of rhinitis in children and adolescents and to analyse their relationship with the prevalence of asthma.
METHODS:A multicentre study was conducted using the methodology of the International Study of Asthma and Allergies in Childhood (ISAAC). The target population of the study was all those school children aged 6–7 and 13–14 years from 6 of the main health catchment areas of Galicia (1.9 million inhabitants). The schools required were randomly selected, and all children in the targeted age ranges were included. Multiple logistic regression was used to obtain adjusted prevalence odds ratios (OR) between asthma symptoms of the schoolchildren and rhinitis prevalence. The results were adjusted for parental smoking habits, maternal education level, cat and dog exposure, and obesity.
RESULTS:A total of 21,420 valid questionnaires were finally obtained. Rhinitis was associated with a significant increase in the prevalence of asthma in both age groups. The highest OR were 11.375 for exercise induced asthma (EIA) for children with recent rhinoconjunctivitis and 9.807 for children with recent rhinitis in 6–7 years old group. The prevalence OR’s are higher in EIA and severe asthmatics.
CONCLUSIONS:Rhinitis in children and adolescents is associated with a higher prevalence and severity of asthma.
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